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dc.creatorBrenes Sáenz, Juan Carlos
dc.creatorFornaguera Trías, Jaime
dc.date.accessioned2017-12-13T19:49:18Z
dc.date.available2017-12-13T19:49:18Z
dc.date.issued2008-05
dc.identifier.citationhttp://www.sciencedirect.com/science/article/pii/S0304394008003686
dc.identifier.issn0304-3940
dc.identifier.urihttps://hdl.handle.net/10669/73682
dc.description.abstractLittle attention has been directed towards environmental control of sensitivity to natural reward and its possible relationship with other motivated behaviors, besides the well-known effects of environmental enrichment and social isolation on drug self-administration and locomotor sensitization to psychostimulants. Here, we investigate the effects of these rearing conditions on sucrose consumption and preference, and tissue levels of striatal dopamine. The possible relationship among sucrose intake, immobility behavior in the forced swimming test, and dopamine concentration was explored through correlation and regression analyses. Even though all animals preferred sucrose over water, we found, that during postnatal period, isolated rats consumed more sucrose than control or enriched littermates. In isolated rats sucrose intake correlated positively with ventral but not with dorsal striatum dopamine, even when striatal dopamine did not differ among groups. Especially in isolated animals immobility behavior was positively predicted by differences in sucrose intake. The dopamine concentration did not correlate with immobility behavior. Taken together, the present data support previous findings regarding the effects of early life events upon reward-sensitivity and depressive-like behavior, and also provide further evidence about the relationship between these motivated behaviors and the likely role of ventral striatum dopamine in regulating them.es_ES
dc.description.sponsorshipUniversidad de Costa Rica/[422-A6-609]/UCR/Costa Ricaes_ES
dc.language.isoen_USes_ES
dc.sourceNeuroscience Letters, Vol. 436 (2), pp. 278-282es_ES
dc.subjectRewardes_ES
dc.subjectSucrosees_ES
dc.subjectDopaminees_ES
dc.subjectStriatumes_ES
dc.subjectAddictiones_ES
dc.subjectDepressiones_ES
dc.titleEffects of environmental enrichment and social isolation on sucrose consumption and preference: Associations with depressive-like behavior and ventral striatum dopaminees_ES
dc.typeartículo original
dc.identifier.doi10.1016/j.neulet.2008.03.045
dc.description.procedenceUCR::Vicerrectoría de Docencia::Salud::Facultad de Medicina::Escuela de Medicinaes_ES
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Centro de Investigación en Neurociencias (CIN)


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