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dc.creatorCorrales Aguilar, Eugenia
dc.creatorTrilling, Mirko
dc.creatorReinhard, Henrike
dc.creatorFalcone, Valeria
dc.creatorZimmermann, Albert
dc.creatorAdams, Ortwin
dc.creatorSantibanez, Sabine
dc.creatorHengel, Hartmut
dc.date.accessioned2017-07-18T19:43:30Z
dc.date.available2017-07-18T19:43:30Z
dc.date.issued2016-05-18
dc.identifier.citationhttps://link.springer.com/article/10.1007%2Fs00430-016-0457-yes_ES
dc.identifier.issn0300-8584
dc.identifier.otherPMC5003914
dc.identifier.urihttp://hdl.handle.net/10669/30374
dc.description.abstractt IgG responses are fundamental to adaptive immunity and document immunological memory of previous pathogen encounter. While specific antigen recognition is mediated by the variable F(ab′)2 domain of IgG, various effector functions become activated via the constant Fcγ part bridging IgG-opsonized targets to FcγR-expressing immune effector cells. Traditionally, neutralizing IgG is considered the most appropriate correlate of protective humoral immunity to viruses. However, evidence is increasing that antiviral IgG mediates protection to viruses via activation of FcγRs. Using a test system allowing quantitative detection of virus-immune IgG able to activate FcγRs, sera of healthy individuals and vaccinees were assessed with regard to two prototypical human pathogenic viruses: measles and human cytomegalovirus. Marked differences in the capacity of individuals to generate FcγRI-, FcγRIIand FcγRIII-activating responses were noted. Comparison of FcγR-activating IgG with neutralizing and ELISA IgG concentrations did not correlate for HCMV and only very poorly for MV. Since neither neutralizing IgG nor overall IgG responses faithfully predict the activation of FcγRs, only the simultaneous quantification of IgGs activating defined FcγRs will aid to delineate individual “immunograms” of virus IgG immunity. Such new multiparametric assessment of antiviral IgG qualities could be instrumental in defining correlates of protection and disease progression.es_ES
dc.description.sponsorshipDeutsche Forschungsgemeinschaft/[He 2526/6-2, GK1045]//Alemaniaes_ES
dc.description.sponsorshipHelmholtz Association/[VISTRIE VH-VI-242]//es_ES
dc.description.sponsorshipEuropean Commission/[QLRT-2001-01112]//es_ES
dc.description.sponsorshipEuropean Commission/[MRTN-CT-2005-019248]//es_ES
dc.language.isoen_USes_ES
dc.sourceMedical Microbiology and Immunology; Volumen 205, Número 5. 2016es_ES
dc.subjectAntiviral IgGes_ES
dc.subjectFcγRses_ES
dc.subjectELISAes_ES
dc.subjectNeutralizationes_ES
dc.subjectMeasles viruses_ES
dc.subjectHuman cytomegaloviruses_ES
dc.titleHighly individual patterns of virus‑immune IgG effector responses in humanses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.typeArtículo científicoes_ES
dc.identifier.doi10.1007/s00430-016-0457-y
dc.description.procedenceUCR::Investigación::Unidades de Investigación::Ciencias de la Salud::Centro de Investigación en Enfermedades Tropicales (CIET)es_ES
dc.identifier.pmid27193020


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