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Brucella abortus Strain 2308 Wisconsin Genome: Importance of the Definition of Reference Strains
dc.creator | Suárez Esquivel, Marcela | |
dc.creator | Ruiz Villalobos, Nazareth | |
dc.creator | Castillo Zeledón, Amanda | |
dc.creator | Jiménez Rojas, César | |
dc.creator | Martin Roop II, Roy | |
dc.creator | Comerci, Diego J. | |
dc.creator | Barquero Calvo, Elías | |
dc.creator | Chacón Díaz, Carlos | |
dc.creator | Caswell, Clayton C. | |
dc.creator | Baker, Kate S. | |
dc.creator | Chaves Olarte, Esteban | |
dc.creator | Thomson, Nicholas R. | |
dc.creator | Moreno Robles, Edgardo | |
dc.creator | Letesson, Jean J. | |
dc.creator | De Bolle, Xavier | |
dc.creator | Guzmán Verri, Caterina | |
dc.date.accessioned | 2017-07-13T17:55:48Z | |
dc.date.available | 2017-07-13T17:55:48Z | |
dc.date.issued | 2016-09-29 | |
dc.identifier.citation | http://journal.frontiersin.org/article/10.3389/fmicb.2016.01557/full | |
dc.identifier.other | PMC5041503 | |
dc.identifier.uri | https://hdl.handle.net/10669/30355 | |
dc.description.abstract | Brucellosis is a bacterial infectious disease affecting a wide range of mammals and a neglected zoonosis caused by species of the genetically homogenous genus Brucella. As in most studies on bacterial diseases, research in brucellosis is carried out by using reference strains as canonical models to understand the mechanisms underlying host pathogen interactions. We performed whole genome sequencing analysis of the reference strain B. abortus 2308 routinely used in our laboratory, including manual curated annotation accessible as an editable version through a link at https://en.wikiped ia.org/wiki/Brucella#Genomics. Comparison of this genome with two publically available 2308 genomes showed significant differences, particularly indels related to insertional elements, suggesting variability related to the transposition of these elements within the same strain. Considering the outcome of high resolution genomic techniques in the bacteriology field, the conventional concept of strain definition needs to be revised. | es_ES |
dc.description.sponsorship | Wellcome Trust/[098051]//Estados Unidos | es_ES |
dc.description.sponsorship | Consejo Nacional de Rectores//FEES-CONARE/Costa Rica | es_ES |
dc.language.iso | en_US | es_ES |
dc.rights | Atribución 3.0 Costa Rica | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/cr/ | * |
dc.source | Frontiers Microbiology; Volumen 7. 2016 | es_ES |
dc.subject | Brucella | es_ES |
dc.subject | Brucella abortus | es_ES |
dc.subject | Reference genome | es_ES |
dc.subject | Reference strain | es_ES |
dc.subject | WGS | es_ES |
dc.title | Brucella abortus Strain 2308 Wisconsin Genome: Importance of the Definition of Reference Strains | es_ES |
dc.type | artículo original | |
dc.identifier.doi | 10.3389/fmicb.2016.01557 | |
dc.description.procedence | UCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Centro de Investigación en Enfermedades Tropicales (CIET) | es_ES |
dc.description.procedence | UCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP) | es_ES |
dc.identifier.pmid | 27746773 |
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