Brucella abortus Strain 2308 Wisconsin Genome: Importance of the Definition of Reference Strains
artículo original
Fecha
2016-09-29Autor
Suárez Esquivel, Marcela
Ruiz Villalobos, Nazareth
Castillo Zeledón, Amanda
Jiménez Rojas, César
Martin Roop II, Roy
Comerci, Diego J.
Barquero Calvo, Elías
Chacón Díaz, Carlos
Caswell, Clayton C.
Baker, Kate S.
Chaves Olarte, Esteban
Thomson, Nicholas R.
Moreno Robles, Edgardo
Letesson, Jean J.
De Bolle, Xavier
Guzmán Verri, Caterina
Metadatos
Mostrar el registro completo del ítemResumen
Brucellosis is a bacterial infectious disease affecting a wide range of mammals and a
neglected zoonosis caused by species of the genetically homogenous genus Brucella.
As in most studies on bacterial diseases, research in brucellosis is carried out by
using reference strains as canonical models to understand the mechanisms underlying
host pathogen interactions. We performed whole genome sequencing analysis of the
reference strain B. abortus 2308 routinely used in our laboratory, including manual
curated annotation accessible as an editable version through a link at https://en.wikiped
ia.org/wiki/Brucella#Genomics. Comparison of this genome with two publically available
2308 genomes showed significant differences, particularly indels related to insertional
elements, suggesting variability related to the transposition of these elements within the
same strain. Considering the outcome of high resolution genomic techniques in the
bacteriology field, the conventional concept of strain definition needs to be revised.
External link to the item
10.3389/fmicb.2016.01557Colecciones
- Microbiología [1171]
El ítem tiene asociados los siguientes ficheros de licencia: