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dc.creatorPatiño Llano, Arley Camilo
dc.creatorQuintana, Juan Carlos
dc.creatorGutiérrez, José María
dc.creatorRucavado Romero, Alexandra
dc.creatorBenjumea, Dora María
dc.creatorPereañez, Jaime Andrés
dc.date.accessioned2017-07-07T16:35:16Z
dc.date.available2017-07-07T16:35:16Z
dc.date.issued2015
dc.identifier.citationhttp://www.mdpi.com/2072-6651/7/5/1532es_ES
dc.identifier.issn2072-6651
dc.identifier.urihttp://hdl.handle.net/10669/30338
dc.description.abstractRenealmia alpinia (Rottb.) MAAS, obtained by micropropagation (in vitro) and wild forms have previously been shown to inhibit some toxic activities of Bothrops asper snake venom if preincubated before injection. In this study, assays were performed in a murine model in which extracts were administered for three days before venom injection. R. alpinia extracts inhibited lethal activity of B. asper venom injected by intraperitoneal route. Median Effective Dose (ED50) values were 36.6 ± 3.2 mg/kg and 31.7 ± 5.4 mg/kg (p > 0.05) for R. alpinia wild and in vitro extracts, respectively. At a dose of 75 mg/kg, both extracts totally inhibited the lethal activity of the venom. Moreover, this dose prolonged survival time of mice receiving a lethal dose of venom by the intravenous route. At 75 mg/kg, both extracts of R. alpinia reduced the extent of venom-induced pulmonary hemorrhage by 48.0% (in vitro extract) and 34.7% (wild extract), in agreement with histological observations of lung tissue. R. alpinia extracts also inhibited hemorrhage in heart and kidneys, as evidenced by a decrease in mg of hemoglobin/g of organ. These results suggest the possibility of using R. alpinia as a prophylactic agent in snakebite, a hypothesis that needs to be further explored.es_ES
dc.description.sponsorshipComité para el Desarrollo de la Investigación and Sostenibilidad 2014–2015///Colombiaes_ES
dc.description.sponsorshipUniversidad de Antioquia///Colombiaes_ES
dc.description.sponsorshipComité Nacional para el Desarrollo de la Investigación//CONADI/Colombiaes_ES
dc.description.sponsorshipUniversidad Cooperativa de Colombia///Colombiaes_ES
dc.description.sponsorshipUniversidad de Costa Rica//UCR/Costa Ricaes_ES
dc.language.isoen_USes_ES
dc.rightsAtribución-CompartirIgual 3.0 Costa Rica*
dc.rights.urihttp://creativecommons.org/licenses/by-sa/3.0/cr/*
dc.sourceToxins; Volumen 7, Número 5. 2015es_ES
dc.subjectRenealmia alpiniaes_ES
dc.subjectSnake venomes_ES
dc.subjectMetalloproteinaseses_ES
dc.subjectSerine proteinasees_ES
dc.subjectAnti-venom activityes_ES
dc.subjectMicropropagated plantses_ES
dc.titleExtracts of Renealmia alpinia (Rottb.) MAAS Protect against Lethality and Systemic Hemorrhage Induced by Bothrops asper Venom: Insights from a Model with Extract Administration before Venom Injectiones_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.typeArtículo científicoes_ES
dc.identifier.doi10.3390/toxins7051532
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)es_ES
dc.identifier.pmid25941768
dc.identifier.pmidPMC4448161


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Atribución-CompartirIgual 3.0 Costa Rica
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