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dc.creatorLaustsen, Andreas Hougaard
dc.creatorLohse, Brian
dc.creatorLomonte, Bruno
dc.creatorEngmark, Mikael Gerling
dc.creatorGutiérrez, José María
dc.date.accessioned2017-07-07T14:35:15Z
dc.date.available2017-07-07T14:35:15Z
dc.date.issued2015-09-15
dc.identifier.citationhttp://www.sciencedirect.com/science/article/pii/S0041010115300271es_ES
dc.identifier.issn0041-0101
dc.identifier.urihttp://hdl.handle.net/10669/30335
dc.descriptionCarta al editores_ES
dc.description.abstractFor more than 100 years, antivenoms have been produced by traditional methods of immunization of large mammals with mixtures of snake venoms (World Health Organization, 2010 and Gutiérrez et al., 2011). With the introduction of proteomic and transcriptomic tools in the molecular analysis of both venoms (venomics) (Calvete, 2014) and antivenoms (antivenomics) (Calvete, 2011 and Calvete et al., 2014), in combination with the toxicological assessment of venoms, a more in-depth understanding of venom composition and antivenom efficacy is being built. As retrieved from current public databases on Elapidae, values for Median Lethal Dose (LD50) are known for 203 toxins, belonging to seven protein sub-families, originating from 40 species (Fig. 1). Furthermore, the number of elapids for which venom-wide proteomics or transcriptomics studies have been reported has now reached 49 out of 355 described species (our unpublished data; http://www.reptile-database.org). Information is now available for a considerable number of species of high medical relevance.es_ES
dc.language.isoen_USes_ES
dc.sourceToxicon; Volumen 104. 2015es_ES
dc.subjectAnimalses_ES
dc.subjectAntiveninses_ES
dc.subjectElapid Venomses_ES
dc.subjectElapidaees_ES
dc.subjectElapidaees_ES
dc.subjectToxinses_ES
dc.titleSelecting key toxins for focused development of elapid snake antivenoms and inhibitors guided by a Toxicity Scorees_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.typeArtículo científicoes_ES
dc.identifier.doi10.1016/j.toxicon.2015.07.334
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)es_ES
dc.identifier.pmid26238171


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