Pathogenic mechanisms underlying adverse reactions induced by intravenous administration of snake antivenoms
León Montero, Guillermo
Herrera Vega, María
Segura Ruiz, Álvaro
Vargas Arroyo, Mariángela
Gutiérrez, José María
MetadatosMostrar el registro completo del ítem
Snake antivenoms are formulations of immunoglobulins, or immunoglobulin fragments, purified from the plasma of animals immunized with snake venoms. Their therapeutic success lies in their ability to mitigate the progress of toxic effects induced by snake venom components, when administered intravenously. However, due to diverse factors, such as deficient manufacturing practices, physicochemical characteristics of formulations, or inherent properties of heterologous immunoglobulins, antivenoms can induce undesirable adverse reactions. Based on the time lapse between antivenom administration and the onset of clinical manifestations, the World Health Organization has classified these adverse reactions as: 1 – Early reactions, if they occur within the first hours after antivenom infusion, or 2 – late reactions, when occurring between 5 and 20 days after treatment. While all late reactions are mediated by IgM or IgG antibodies raised in the patient against antivenom proteins, and the consequent formation of immune complexes, several mechanisms may be responsible for the early reactions, such as pyrogenic reactions, IgE-mediated reactions, or non IgE-mediated reactions. This work reviews the hypotheses that have been proposed to explain the mechanisms involved in these adverse reactions to antivenoms. The understanding of these pathogenic mechanisms is necessary for the development of safer products and for the improvement of snakebite envenomation treatment.
Enlace externo al ítem10.1016/j.toxicon.2013.09.010
- Microbiología 
Mostrando ítems relacionados por Título, autor o materia.
Venom of the crotaline snake Atropoides nummifer (jumping viper) from Guatemala and Honduras: comparative toxicological characterization, isolation of a myotoxic phospholipase A(2) homologue and neutralization by two antivenoms Rojas Umaña, Ermila; Saravia Otten, Patricia; Angulo, Yamileth; Arce, Viviana; Lomonte, Bruno; Chávez, Juan José; Velásquez, Rubén; Thelestam, Mónica; Gutiérrez, José María (2001-07)A comparative study was performed on the venoms of the crotaline snake Atropoides nummifer from Guatemala and Honduras. SDS-polyacrylamide gel electrophoresis, under reducing conditions, revealed a highly similar pattern ...
Acuña Espinoza, Alejandro; Aragón Vargas, Luis Fernando (2014-04-04)This study shows, through an experimental approach supported by a metrological approach, the falsehood of the myth among wrestlers and wrestling trainers that reported mass will decrease if a man remains in a headstand ...
González Argüello, Ronald (2007-06-01)La farmacovigilancia es el estudio de los daños relacionados a los medicamentos con el propósito de realizar advertencias o recomendaciones de retiro de productos farmacéuticos. Hasta ahora no existen datos sobre la ...