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dc.creatorGutiérrez, José María
dc.date.accessioned2017-06-08T20:20:17Z
dc.date.available2017-06-08T20:20:17Z
dc.date.issued2016-01
dc.identifier.citationhttp://www.sciencedirect.com/science/article/pii/S0041010115301392es_ES
dc.identifier.issn0041-0101
dc.identifier.urihttp://hdl.handle.net/10669/30072
dc.description.abstractDuring 45 years, the Instituto Clodomiro Picado (ICP, University of Costa Rica) has developed an ambitious scientific, technological, productive, and social program aimed at providing a better understanding of snakes and their venoms, contributing to the development, production and distribution of antivenoms, improving the prevention and management of snakebite envenomings, and strengthening human resources in science and technology. Among other topics, its research agenda has focused on the local tissue alterations induced by viperid snake venoms, i.e. myonecrosis, hemorrhage, dermonecrosis, extracellular matrix degradation, lymphatic vessel damage, and inflammation. In addition, the preclinical efficacy of antivenoms has been thoroughly investigated, together with the technological development of novel antivenoms. ICP's project has been based on a philosophical frame characterized by: (a) An integrated approach for confronting the problem of snakebites, involving research, production, extension activities, and teaching; (b) a cooperative and team work perspective in the pursuit of scientific, technological, productive, and social goals; (c) a search for excellence and continuous improvement in the quality of its activities; and (d) a vision of solidarity and compassion, based on the realization that snakebite envenomings mostly affect impoverished vulnerable populations in the rural settings of developing countries. A key aspect in this program has been the consolidation of international partnerships with groups of all continents, within a frame of academic and social cooperation, some of which are described in this review.es_ES
dc.description.sponsorshipUniversidad de Costa Rica//UCR/Costa Ricaes_ES
dc.language.isoen_USes_ES
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 Costa Rica*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cr/*
dc.sourceToxicon; Volumen 109. 2015es_ES
dc.subjectCosta Ricaes_ES
dc.subjectToxinologyes_ES
dc.subjectSnake venomes_ES
dc.subjectAntivenomes_ES
dc.subjectMyonecrosises_ES
dc.subjectHemorrhagees_ES
dc.subjectNeutralizationes_ES
dc.subjectBothrops asperes_ES
dc.titleUnderstanding and confronting snakebite envenoming: The harvest of cooperationes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.typeArtículo científicoes_ES
dc.identifier.doi10.1016/j.toxicon.2015.11.013
dc.description.procedenceUCR::Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)es_ES
dc.identifier.pmid26615826


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