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dc.creatorGutiérrez, José María
dc.creatorRojas Céspedes, Gustavo
dc.creatorLomonte, Bruno
dc.creatorGené, José Antonio
dc.creatorCerdas Fallas, Luis
dc.date.accessioned2017-06-06T21:03:52Z
dc.date.available2017-06-06T21:03:52Z
dc.date.issued1987
dc.identifier.citationhttp://www.sciencedirect.com/science/article/pii/0041010187901449es_ES
dc.identifier.issn0041-0101
dc.identifier.urihttp://hdl.handle.net/10669/29948
dc.description.abstractThe myotoxin from B. asper snake venom inhibited Ca-ATPase activity of rabbit sarcoplasmic reticulum after incubation in vitro. Inhibition was non-competitive and albumin enhanced the effect of the toxin. Furthermore, B. asper myotoxin hydrolyzed sarcoplasmic reticulum phospholipids and induced a dose-dependent release of horseradish peroxidase that had been trapped in sarcoplasmic reticulum vesicles. Binding studies indicated that myotoxin does not bind to any particular protein of this membrane, suggesting that the toxin might interact with phospholipids. Inhibition of Ca-ATPase is probably a consequence of an alteration in sarcoplasmic reticulum phospholipids.es_ES
dc.description.sponsorshipUniversidad de Costa Rica/[Vi-741-84-085]/UCR/Costa Ricaes_ES
dc.language.isoen_USes_ES
dc.sourceToxicon; Volumen 25, Número 11. 1987es_ES
dc.subjectMyotoxines_ES
dc.subjectBothrops asperes_ES
dc.subjectVenomes_ES
dc.subjectSnake venomes_ES
dc.titleEffects of a myotoxic phospholipase A2 isolated from Bothrops asper venom on skeletal muscle sarcoplasmic reticulumes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.typeArtículo científicoes_ES
dc.identifier.doi10.1016/0041-0101(87)90144-9
dc.description.procedenceUCR::Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)es_ES
dc.identifier.pmid2963409


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