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dc.creatorLopes Ferreira, Mónica
dc.creatorMoura Da Silva, Ana M.
dc.creatorPiran Soares, Ana Amélia
dc.creatorAngulo Ugalde, Yamileth
dc.creatorLomonte, Bruno
dc.creatorGutiérrez, José María
dc.creatorFarsky, Sandra H. P.
dc.date.accessioned2017-02-02T17:26:34Z
dc.date.available2017-02-02T17:26:34Z
dc.date.issued2002-08
dc.identifier.citationhttp://www.sciencedirect.com/science/article/pii/S0041010102001149es_ES
dc.identifier.issn0041-0101
dc.identifier.urihttp://hdl.handle.net/10669/29485
dc.description.abstractAccidents by Thalassophryne nattereri fish venom are characterised by severe local symptoms and signs including pain of fast onset, oedema and necrosis with impaired muscle regeneration. These effects have been related to alterations in hemostatic mechanisms and cytolytic effects rather than to conventional inflammatory pathways. In this work we evaluated the effects induced by the venom on microcirculatory vessels, platelets and blood coagulation. Effects evoked by topical application of venom on cremaster muscle were visualised through intravital microscopy. Stasis was observed, concomitantly with the presence of thrombi in venules and focal transient constrictions in arterioles, all of which impaired the blood flow. Significant alterations on vessel walls took place few minutes after venom application, characterised by increment in thickness, probably by deposition of fibrin. Increase in vascular permeability was also observed in venules. Additionally, the action of the venom was locally restricted since no alteration on systemic blood coagulation was observed. Venom lacked a direct pro-coagulant activity, but exerted a strong cytolytic effect on platelets and endothelial cells in vitro. These data suggest that venom action on endothelium may contribute to blood stasis and to the formation of platelet and fibrin thrombi, with the consequent ischemia, contributing to the local effects of the venom.es_ES
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo//FAPESP/Brasiles_ES
dc.language.isoen_USes_ES
dc.sourceToxicon; Volumen 40, Número 8, 2002es_ES
dc.subjectThalassophryne Nattereri Fish Venomes_ES
dc.subjectMicrocirculationes_ES
dc.subjectBlood Coagulationes_ES
dc.subjectNecrosises_ES
dc.subjectIntravital Microscopyes_ES
dc.subjectEndotheliumes_ES
dc.subjectCytolysines_ES
dc.titleHemostatic effects induced by Thalassophryne nattereri fish venom: a model of endothelium-mediated blood flow impairment.es_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.identifier.doi10.1016/S0041-0101(02)00114-9
dc.description.procedenceUCR::Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)es_ES
dc.identifier.pmid12165317


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