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dc.creatorLeón Montero, Guillermo
dc.creatorStiles, Bradley G.
dc.creatorAlape Girón, Alberto
dc.creatorRojas Céspedes, Gustavo
dc.creatorGutiérrez, José María
dc.date.accessioned2017-01-23T20:48:30Z
dc.date.available2017-01-23T20:48:30Z
dc.date.issued1999-08
dc.identifier.citationhttp://www.ajtmh.org/content/61/2/266.longes_ES
dc.identifier.issn0002-9637
dc.identifier.urihttp://hdl.handle.net/10669/29454
dc.description.abstractA comparative study was performed on the ability of IgG and F(ab')2 antivenoms to neutralize lethal and myotoxic activities of Micrurus nigrocinctus venom. Both antivenoms were adjusted to a similar neutralizing potency in experiments where venom and antivenoms were preincubated prior to injection. No significant differences were observed between IgG and F(ab')2 antivenoms concerning neutralization of lethal effect in rescue experiments, i.e., when antivenom was administered intravenously after envenomation. However, F(ab')2 antivenom was more effective in prolonging the time of death when subneutralizing doses were administered immediately after venom injection. Both products partially reversed the binding of M. nigrocinctus alpha-neurotoxins to acetylcholine receptor in vitro. The IgG and F(ab')2 antivenoms effectively neutralized venom-induced myotoxicity when administered intravenously immediately after envenomation, although neutralization was poor if antivenom injections were delayed. Intramuscular injection of venom promoted diffusion of antivenom antibodies throughout muscle tissue, and F(ab')2 diffused to a higher extent than IgG molecules. Thus, despite the observation that F(ab')2 antivenom was more effective than IgG antivenom in prolonging the time of death when subneutralizing doses were administered immediately after envenomation, no major differences were observed in antivenom neutralization of lethal and myotoxic effects or in their capacity to reverse neurotoxin binding to the acetylcholine receptor.es_ES
dc.description.sponsorshipUniversidad de Costa Rica/[741-89-057]/UCR/Costa Ricaes_ES
dc.language.isoen_USes_ES
dc.sourceThe American Journal of Tropical Medicine and Hygiene; Volumen 61, Número 2. 1999es_ES
dc.subjectAnimalses_ES
dc.subjectAntibodieses_ES
dc.subjectAntiveninses_ES
dc.subjectElapid Venomses_ES
dc.subjectElapidaees_ES
dc.subjectEnzyme-Linked Immunosorbent Assayes_ES
dc.subjectImmunoglobulin Fab Fragmentses_ES
dc.subjectImmunoglobulin Ges_ES
dc.subjectInjections, Intramusculares_ES
dc.subjectInjections, Intraperitoneales_ES
dc.subjectInjections, Intravenouses_ES
dc.subjectLethal Dose 50es_ES
dc.subjectMicees_ES
dc.subjectNeurotoxinses_ES
dc.subjectNeutralization Testses_ES
dc.subjectSnake venomes_ES
dc.titleComparative study on the ability of IgG and F(ab')2 antivenoms to neutralize lethal and myotoxic effects induced by Micrurus nigrocinctus (coral snake) venomes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.typeArtículo científicoes_ES
dc.description.procedenceUCR::Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)es_ES
dc.identifier.codproyecto741-89-057


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