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dc.creatorGlei, Dana
dc.creatorRisques, Rosa Ana
dc.creatorRehkopf, David H.
dc.creatorDow, William H.
dc.creatorRosero Bixby, Luis
dc.creatorWeinstein, Maxine
dc.creatorGoldman, Noreen
dc.date.accessioned2016-12-06T18:44:57Z
dc.date.available2016-12-06T18:44:57Z
dc.date.issued2016-04
dc.identifier.citationhttp://journals.plos.org/plosone/article/asset?id=10.1371/journal.pone.0152486.PDFes_ES
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/10669/29356
dc.description.abstractTelomere length has generated substantial interest as a potential predictor of aging- related diseases and mortality. Some studies have reported significant associations, but few have tested its ability to discriminate between decedents and survivors compared with a broad range of well-established predictors that include both biomarkers and commonly collected self-reported data. Our aim here was to quantify the prognostic value of leuko- cyte telomere length relative to age, sex, and 19 other variables for predicting five-year mortality among older persons in three countries. We used data from nationally represen- tative surveys in Costa Rica (N = 923, aged 61+), Taiwan (N = 976, aged 54+), and the U. S. (N = 2672, aged 60+). Our study used a prospective cohort design with all-cause mor- tality during five years post-exam as the outcome. We fit Cox hazards models separately by country, and assessed the discriminatory ability of each predictor. Age was, by far, the single best predictor of all-cause mortality, whereas leukocyte telomere length was only somewhat better than random chance in terms of discriminating between decedents and survivors. After adjustment for age and sex, telomere length ranked between 15th and 17th (out of 20), and its incremental contribution was small; nine self-reported variables (e.g., mobility, global self-assessed health status, limitations with activities of daily living, smoking status), a cognitive assessment, and three biological markers (C-reactive protein, serum creatinine, and glycosylated hemoglobin) were more powerful predictors of mortality in all three countries. Results were similar for cause-specific models (i.e., mortality from cardiovascular disease, cancer, and all other causes combined). Leukocyte telomere length had a statistically discernible, but weak, association with mortality, but it did not predict survival as well as age or many other self-reported variables. Although telomere length may eventually help scientists understand aging, more powerful and more easily obtained tools are available for predicting survival.es_ES
dc.description.sponsorshipNational Institute on Aginges_ES
dc.description.sponsorshipEunice Kennedy Shriver National Institute of Child Health and Human Developmentes_ES
dc.description.sponsorshipWellcome Trustes_ES
dc.language.isoen_USes_ES
dc.sourcePLOS One; Volumen 11, Número 4. 2016es_ES
dc.subjectCohort Studieses_ES
dc.subjectCosta Ricaes_ES
dc.subjectFemalees_ES
dc.subjectHumanses_ES
dc.subjectMalees_ES
dc.subjectMiddle Agedes_ES
dc.subjectTelomerees_ES
dc.subjectUnited Stateses_ES
dc.titlePredicting Survival from Telomere Length versus Conventional Predictors: A Multinational Population-Based Cohort Studyes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.typeArtículo científicoes_ES
dc.identifier.doi10.1371/journal.pone.0152486
dc.description.procedenceUCR::Investigación::Unidades de Investigación::Ciencias Sociales::Centro Centroamericano de Población (CCP)es_ES


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