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dc.creatorCintra Francischinelli, Marianaes_ES
dc.creatorCaccin, Paolaes_ES
dc.creatorChiavegato, Angelaes_ES
dc.creatorPizzo, Paolaes_ES
dc.creatorCarmignoto, Giorgioes_ES
dc.creatorAngulo Ugalde, Yamilethes_ES
dc.creatorLomonte, Brunoes_ES
dc.creatorGutiérrez, José Maríaes_ES
dc.creatorMontecucco, Cesarees_ES
dc.date.accessioned2016-11-28T21:16:20Zes_ES
dc.date.available2016-11-28T21:16:20Zes_ES
dc.date.issued2010-07-26es_ES
dc.identifier.citationhttp://www.pnas.org/content/107/32/14140es_ES
dc.identifier.issn0027-8424es_ES
dc.identifier.urihttp://hdl.handle.net/10669/29327es_ES
dc.description.abstractMyotoxins play a major role in the pathogenesis of the envenomations caused by snake bites in large parts of the world where this is a very relevant public health problem. We show here that two myotoxins that are major constituents of the venom of Bothrops asper, a deadly snake present in Latin America, induce the release of large amounts of K+ and ATP from skeletal muscle. We also show that the released ATP amplifies the effect of the myotoxins, acting as a “danger signal,” which spreads and causes further damage by acting on purinergic receptors. In addition, the release of ATP and K+ well accounts for the pain reaction characteristic of these envenomations. As Bothrops asper myotoxins are representative of a large family of snake myotoxins with phospholipase A2 structure, these findings are expected to be of general significance for snake bite envenomation. Moreover, they suggest potential therapeutic approaches for limiting the extent of muscle tissue damage based on antipurinergic drugs.es_ES
dc.description.sponsorshipInternational Centre for Genetic Engineering and Biotechnology/[COS-08-03]/ICGEB/Italiaes_ES
dc.description.sponsorshipUniversidad de Costa Rica//UCR/Costa Ricaes_ES
dc.language.isoen_USes_ES
dc.sourceProccedings of the National Academy of Sciences of the United States of America (PNAS); Volumen 107, Número 32. 2010es_ES
dc.subjectMuscle Damagees_ES
dc.subjectPhospholipases A2es_ES
dc.subjectC2C12 Cellses_ES
dc.subjectSnake venomes_ES
dc.titleBothrops snake myotoxins induce a large efflux of ATP and potassium with spreading of cell damage and paines_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.typeArtículo científicoes_ES
dc.identifier.doi10.1073/pnas.1009128107es_ES
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)es_ES


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