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dc.creatorGutiérrez, José María
dc.creatorRucavado Romero, Alexandra
dc.creatorChaves Mora, Fernando
dc.creatorDíaz Oreiro, Cecilia
dc.creatorEscalante Muñoz, Teresa
dc.date.accessioned2016-11-16T19:15:22Z
dc.date.available2016-11-16T19:15:22Z
dc.date.issued2009-12-01
dc.identifier.citationhttp://www.sciencedirect.com/science/article/pii/S0041010109001627es_ES
dc.identifier.issn0041-0101
dc.identifier.urihttp://hdl.handle.net/10669/29253
dc.description.abstractEnvenomations by Bothrops asper are often associated with complex and severe local pathological manifestations, including edema, blistering, dermonecrosis, myonecrosis and hemorrhage. The pathogenesis of these alterations has been investigated at the experimental level. These effects are mostly the consequence of the direct action of zinc-dependent metalloproteinases (SVMPs) and myotoxic phospholipases A2 (PLA2s). SVMPs induce hemorrhage, blistering, dermonecrosis and general extracellular matrix degradation, whereas PLA2s induce myonecrosis and also affect lymphatic vessels. In addition, the prominent vascular alterations leading to hemorrhage and edema may contribute to ischemia and further tissue necrosis. The mechanisms of action of SVMPs and PLA2s are discussed in detail in this review. Venom-induced tissue damage plays also a role in promoting bacterial infection. A prominent inflammatory reaction develops as a consequence of these local pathological alterations, with the synthesis and release of abundant mediators, resulting in edema and pain. However, whether inflammatory cells and mediators contribute to further tissue damage is not clear at present. Muscle tissue regeneration after venom-induced pathological effects is often impaired, thus resulting in permanent tissue loss and dysfunction. SVMP-induced microvessel damage is likely to be responsible of this poor regenerative outcome. Antivenoms are only partially effective in the neutralization of B. asper-induced local effects, and the search for novel toxin inhibitors represents a potential avenue for improving the treatment of this serious aspect of snakebite envenomation.es_ES
dc.language.isoen_USes_ES
dc.sourceToxicon; Volumen 54, Número 7, Pages 958–975, 2009es_ES
dc.subjectBothrops asperes_ES
dc.subjectLocal effectses_ES
dc.subjectHemorrhagees_ES
dc.subjectMyonecrosises_ES
dc.subjectEdemaes_ES
dc.subjectBlisteringes_ES
dc.subjectMuscle regenerationes_ES
dc.subjectMetalloproteinaseses_ES
dc.subjectPhospholipases A2es_ES
dc.subjectSnake venomes_ES
dc.titleExperimental pathology of local tissue damage induced by Bothrops asper snake venomes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.typeArtículo científicoes_ES
dc.identifier.doi10.1016/j.toxicon.2009.01.038
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)es_ES


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