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dc.creatorGutiérrez, José María
dc.creatorEscalante Muñoz, Teresa
dc.creatorRucavado Romero, Alexandra
dc.date.accessioned2016-11-16T17:17:09Z
dc.date.available2016-11-16T17:17:09Z
dc.date.issued2009-12-01
dc.identifier.citationhttp://www.sciencedirect.com/science/article/pii/S0041010109001639es_ES
dc.identifier.issn0041-0101
dc.identifier.urihttp://hdl.handle.net/10669/29252
dc.description.abstractModerate and severe envenomations by the snake Bothrops asper provoke systemic alterations, such as systemic bleeding, coagulopathy, hypovolemia, hemodynamic instability and shock, and acute renal failure. Systemic hemorrhage is a typical finding of these envenomations, and is primarily caused by the action of P-III snake venom metalloproteinases (SVMPs). This venom also contains a thrombin-like serine proteinase and a prothrombin-activating P-III SVMP, both of which cause defibrin(ogen)ation. Thrombocytopenia, predominantly induced by a C-type lectin-like protein, and platelet hypoaggregation, caused by the two defibrin(ogen)ating enzymes, also contribute to hemostatic disturbances, which potentiate the systemic bleeding induced by hemorrhagic SVMPs. Cardiovascular disturbances leading to shock are due to the combined effects of hemorrhagic toxins, other venom components that increase vascular permeability, the action of hypotensive agents in the venom and of endogenous mediators, and the potential cardiotoxic effect of some toxins. Renal alterations are likely to be caused by direct cytotoxicity of venom components in the kidney, and by renal ischemia resultant from hypovolemia and hypoperfusion. Lethality induced by B. asper venom is the consequence of several combined effects among which the action of P-III SVMPs is especially relevant.es_ES
dc.description.sponsorshipSweden-Central America NeTropicaes_ES
dc.description.sponsorshipUniversidad de Costa Ricaes_ES
dc.description.sponsorshipInternational Foundation for Science (IFS)es_ES
dc.language.isoen_USes_ES
dc.sourceToxicon; Volumen 54, Número 7. 2009es_ES
dc.subjectBothrops asperes_ES
dc.subjectSystemic effectses_ES
dc.subjectHemorrhagees_ES
dc.subjectCoagulopathyes_ES
dc.subjectThrombocytopeniaes_ES
dc.subjectHypoaggregationes_ES
dc.subjectRenal failurees_ES
dc.subjectCardiovascular shockes_ES
dc.subjectMetalloproteinaseses_ES
dc.subjectSnake venomes_ES
dc.titleExperimental pathophysiology of systemic alterations induced by Bothrops asper snake venomes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.typeArtículo científicoes_ES
dc.identifier.doi10.1016/j.toxicon.2009.01.039
dc.description.procedenceUCR::Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)es_ES


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