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dc.creatorChaves Mora, Fernando
dc.creatorGutiérrez, José María
dc.creatorBrenes Pino, Fernando
dc.date.accessioned2016-11-10T15:52:06Z
dc.date.available2016-11-10T15:52:06Z
dc.date.issued1992-09
dc.identifier.issn0041-0101
dc.identifier.urihttp://hdl.handle.net/10669/29180
dc.description.abstractVenom from newborn Bothrops asper snakes has higher lethal, hemorrhagic, edema-forming, proteolytic and defibrinating activities than venom from adult B. asper specimens. Electrophoretic analysis confirmed the variation between these venoms. Intramuscular injection of 100 micrograms of venom from newborn specimens in mice induced defibrination, together with moderate increments of serum levels of lactate dehydrogenase, creatine kinase, hemoglobin and total proteins. A conspicuous hemorrhage developed in injected muscle rapidly after envenomation, probably due to a drastic alteration in capillaries and larger blood vessels. Other histological alterations included moderate myonecrosis, lung collapse and prominent renal damage, characterized by tubular necrosis and hyalinization. Polyvalent antivenom effectively neutralized lethal, hemorrhagic and indirect hemolytic activities of newborn B. asper venom, although requiring higher antivenom doses than neutralization of venom from adult B. asper.es_ES
dc.language.isoen_USes_ES
dc.sourceToxicon; Volumen 30, Número 9, 1992es_ES
dc.subjectAnimalses_ES
dc.subjectNewbornes_ES
dc.subjectAntiveninses_ES
dc.subjectBlood Coagulationes_ES
dc.subjectCrotalid Venomses_ES
dc.subjectEdemaes_ES
dc.subjectElectrophoresis, Polyacrylamide Geles_ES
dc.subjectEnzymeses_ES
dc.subjectHemoglobinses_ES
dc.subjectHemolysises_ES
dc.subjectHemorrhagees_ES
dc.subjectInjections, Intramusculares_ES
dc.subjectMicees_ES
dc.subjectNeutralization Testses_ES
dc.subjectMuscleses_ES
dc.titlePathological and biochemical changes induced in mice after intramuscular injection of venom from newborn specimens of the snake Bothrops asper (Terciopelo)es_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.typeArtículo científicoes_ES
dc.identifier.doi10.1016/0041-0101(92)90055-A
dc.description.procedenceUCR::Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)es_ES


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