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dc.creatorMoreira Carmona, Lisela
dc.creatorGutiérrez, José María
dc.creatorBorkow, Gadi
dc.creatorOvadia, Michael
dc.date.accessioned2016-11-10T15:29:16Z
dc.date.available2016-11-10T15:29:16Z
dc.date.issued1992-10
dc.identifier.issn0014-4800
dc.identifier.urihttp://hdl.handle.net/10669/29178
dc.description.abstractHistological and ultrastructural alterations in capillary blood vessels were studied at various time intervals after im injection of 50 micrograms of Bothrops asper snake venom in mouse gastrocnemius muscle. Hemorrhage was observed as early as 5 min after envenomation, as abundant erythrocytes appeared in the interstitial space. Ultrastructural observations revealed two different patterns of pathological changes: in the majority of damaged capillaries, endothelial cells had blebs and cytoplasmic projections pinching off to the lumen. This phenomenon was observed together with a decrease in the number of pinocytotic vesicles, with endothelial cells becoming very thin. As an apparent consequence of this process, some endothelial cells had evident gaps in their continuity. In addition, basal laminae surrounding these capillaries were altered and discontinuous. Other endothelial cells underwent a morphologically different process of degeneration, characterized by swelling of the endoplasmic reticulum and of the cytosol. These cells had a diffuse appearance and their basal laminae were discontinuous or absent. No major changes in the intercellular junctions were noticed in damaged endothelial cells. Samples obtained 30 and 60 min after venom injection were devoid of normal capillaries in many areas, and only diffuse remnants of their structure were found. Many altered capillaries had platelet aggregates and fibrin, the latter also being observed in the interstitial space. It is concluded that B. asper venom induces rapid and drastic pathological effects on capillaries leading to hemorrhage per rhexis i.e., erythrocytes probably escape through gaps in damaged endothelial cells and not through widened intercellular junctions.es_ES
dc.language.isoen_USes_ES
dc.sourceExperimental and Molecular Pathology; Volumen 57, Número 2, 1992es_ES
dc.subjectAnimalses_ES
dc.subjectCapillarieses_ES
dc.subjectCrotalid Venomses_ES
dc.subjectEndothelium, Vasculares_ES
dc.subjectHemorrhagees_ES
dc.subjectMicees_ES
dc.subjectMicroscopy, Electrones_ES
dc.subjectTime Factorses_ES
dc.subjectSnake venomes_ES
dc.titleUltrastructural alterations in mouse capillary blood vessels after experimental injection of venom from the snake Bothrops asper (Terciopelo)es_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.typeArtículo científicoes_ES
dc.identifier.doi10.1016/0014-4800(92)90004-U
dc.description.procedenceUCR::Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)es_ES
dc.description.procedenceUCR::Docencia::Salud::Facultad de Microbiologíaes_ES


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