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dc.creatorQuirós, Shirley
dc.creatorGené, José Antonio
dc.creatorGutiérrez, José María
dc.creatorThelestam, Mónica
dc.date.accessioned2016-11-10T14:53:00Z
dc.date.available2016-11-10T14:53:00Z
dc.date.issued1992-02
dc.identifier.issn0306-4492
dc.identifier.urihttp://hdl.handle.net/10669/29174
dc.description.abstract1. The effect of Bothrops asper venom on erythrocytes of different species, sheep erythrocyte ghost vesicles and liposomes made of phospholipids from sheep erythrocytes was studied. 2. B. asper venom had a direct hemolytic effect on mouse erythrocytes, but no lytic activity on goat, rabbit, horse, toad and sheep erythrocytes. Human erythrocytes were lysed only in the presence of bovine serum albumin and Ca2+. 3. Although the phospholipase A2 activity in the venom might be involved in the lytic effect on mouse erythrocytes, there is also evidence of direct lytic factor(s) acting in the absence of calcium ions. 4. Sheep erythrocytes were modified in order to study the basis of their resistance. Enhancement of membrane fluidity and variation of pH were of no consequence for the resistance of sheep erythrocytes to the action of venom. 5. The reorganization of membranes that takes place during ghost or liposome preparation made them susceptible to B. asper venom-induced disruption. Thus the resistance of sheep erythrocytes seems related to the accessibility of the target.es_ES
dc.language.isoen_USes_ES
dc.sourceComparative Biochemistry and Physiology Part C: Comparative Pharmacology 101(2): 433436, 1992es_ES
dc.subjectAnimalses_ES
dc.subjectAnuraes_ES
dc.subjectCalciumes_ES
dc.subjectCrotalid Venomses_ES
dc.subjectErythrocyte Membranees_ES
dc.subjectGoatses_ES
dc.subjectHemolysises_ES
dc.subjectHorseses_ES
dc.subjectHumanses_ES
dc.subjectHydrogen-Ion Concentrationes_ES
dc.subjectLiposomeses_ES
dc.subjectMembrane Fluidityes_ES
dc.subjectMicees_ES
dc.subjectRabbitses_ES
dc.subjectSerum Albumin, Bovinees_ES
dc.subjectSheepes_ES
dc.subjectSpecies Specificityes_ES
dc.titleEffect of Bothrops asper (Fer-De-Lance) snake venom on erythrocyte membrane. A comparative studyes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.typeArtículo científicoes_ES
dc.identifier.doi10.1016/0742-8413(92)90299-M
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)es_ES


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