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dc.creatorChaves Mora, Fernando
dc.creatorGutiérrez, José María
dc.creatorLomonte, Bruno
dc.creatorCerdas Fallas, Luis
dc.date.accessioned2016-11-07T17:38:03Z
dc.date.available2016-11-07T17:38:03Z
dc.date.issued1989
dc.identifier.citationhttp://www.sciencedirect.com/science/article/pii/0041010189900020es_ES
dc.identifier.issn0041-0101
dc.identifier.urihttp://hdl.handle.net/10669/29157
dc.description.abstractThe local and systemic pathological changes induced by an i.m. injection of 100 micrograms of Bothrops asper venom in mice were studied histologically and by following the changes in serum levels of enzymes, proteins, ATP and lactate, as well as alterations in hematocrit and clotting time. B. asper venom induced a rapid and marked increase in serum levels of creatine kinase, aspartate aminotransferase and lactate dehydrogenase, but not alanine aminotransferase or alkaline phosphatase. A local myonecrosis and hemorrhage was observed, with the lungs collapsing by 24 hr and the kidneys showing glomerular congestion and vacuolar degeneration of tubular cells. Only minor histopathological changes were observed in cardiac muscle and liver. Both ATP and lactate blood levels decreased after venom injection, whereas there were no changes in serum protein concentration. Blood incoagulability was observed 1 and 3 hr after envenomation. Antivenom neutralized venom-induced increases in serum enzyme levels following preincubation with venom, indicating that antivenom contains antibodies against tissue-damaging toxins. However, when antivenom was administered i.v. at different time intervals after venom injection, neutralization was only partial, with the exception of defibrinating activity, which was totally neutralized even after a delay of 1 hr in administering antivenom.es_ES
dc.language.isoen_USes_ES
dc.sourceToxicon 27(10):1085-1093. 1989es_ES
dc.subjectAdenosine Triphosphatees_ES
dc.subjectAnimalses_ES
dc.subjectAntiveninses_ES
dc.subjectBlood Coagulationes_ES
dc.subjectBlood Proteinses_ES
dc.subjectCrotalid Venomses_ES
dc.subjectHematocrites_ES
dc.subjectInjectionses_ES
dc.subjectLactateses_ES
dc.subjectMicees_ES
dc.subjectMuscular Diseaseses_ES
dc.subjectTime Factorses_ES
dc.subjectSnake venomes_ES
dc.titleHistopathological and biochemical alterations induced by intramuscular injection of Bothrops asper (terciopelo) venom in micees_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.typeArtículo científicoes_ES
dc.identifier.doi10.1016/0041-0101(89)90002-0
dc.description.procedenceUCR::Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)es_ES


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