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dc.creatorGutiérrez, José Maríaes_ES
dc.creatorRojas Céspedes, Gustavoes_ES
dc.creatorLomonte, Brunoes_ES
dc.creatorGené, José Antonioes_ES
dc.creatorCerdas Fallas, Luises_ES
dc.date.accessioned2016-11-04T19:39:36Zes_ES
dc.date.available2016-11-04T19:39:36Zes_ES
dc.date.issued1986es_ES
dc.identifier.citationhttp://www.sciencedirect.com/science/article/pii/0742841386900691es_ES
dc.identifier.urihttp://hdl.handle.net/10669/29144es_ES
dc.description.abstractThe edema-forming activity of eight Costa Rican crotaline snake venoms and its neutralization by a polyvalent antivenom were studied using the mouse footpad test. All of the venoms induced edema, the highest activity being present in the venoms of Bothrops lateralis and Bothrops picadoi. When experiments were performed with preincubation of venom and antivenom, neutralization of edema was poor. Moreover, it was observed that, with some venoms, edema increased when large doses of antivenom were used. This effect was also observed when some venoms were incubated with coral snake antivenom, suggesting that venoms may release some pharmacologically active component(s) from antivenom, since the latter contains traces of alpha-2 and beta globulins. Based on these findings, an alternative approach to the study of the neutralization of edema was used; in this new method, antivenom was injected i.v. before venom administration, thereby avoiding preincubation. With this technique, a much better neutralization of edema was observed, although with some venoms it was still poor. Venoms contain low molecular weight factors which induce edema, suggesting that lack of immunogenicity of some components may cause a poor neutralization. However, such components are responsible for only a minor portion of the edema induced by crude venoms. It is suggested that experiments in which venom and antivenom are preincubated preincubated in testing the neutralization of edema should be avoided, and that a more adequate approach may be an independent inoculation of venom and antivenom.es_ES
dc.language.isoen_USes_ES
dc.sourceComparative Biochemistry and Physiology Part C: Comparative Pharmacology, Volumen 85, Número 1, 1986es_ES
dc.subjectAnimalses_ES
dc.subjectAntiveninses_ES
dc.subjectCrotalid Venomses_ES
dc.subjectEdemaes_ES
dc.subjectprevention & controles_ES
dc.subjectMolecular Weightes_ES
dc.subjectSnake venomes_ES
dc.titleComparative study of the edema-forming activity of Costa Rican snake venoms and its neutralization by a polyvalent antivenomes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.identifier.doi10.1016/0742-8413(86)90069-1es_ES
dc.description.procedenceUCR::Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)es_ES


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