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Discovery of Tricyclic Clerodane Diterpenes as Sarco/Endoplasmic Reticulum Ca2+-ATPase Inhibitors and Structure−Activity Relationships
(2015-05-20)
Tricyclic clerodane diterpenes (TCDs) are natural compounds that often show potent cytotoxicity for cancer cells, but their mode of action remains elusive. A computationally based similarity search (CDRUG), combined with ...
Isolation of Flavonoids from Deguelia duckeana and Their Effect on Cellular Viability, AMPK, eEF2, eIF2 and eIF4E
(2016)
Preparations of Deguelia duckeana, known in Brazil as timbó, are used by indigenous people to kill fish. Reinvestigation of its extracts resulted in the isolation and identification of 11 known flavonoids identified as ...
Life cycle and in vitro sporulation dynamics of Corinectria constricta, the causal agent of Pinus radiata stem canker, in Chile
(2020-04-07)
In 2008, a canker disease caused by the fungus Corinectria constricta was detected in southern Chile. The causal agent was previously identified as Neonectria fuckeliana (now Corinectria fuckeliana), which has been associated ...
Leaf and flower essential oil compositions of Gliricidia sepium (Fabaceae) from Costa Rica
(2015-04)
Gliricidia is a small genus of flowering plants in the Fabaceae family. Gliricidia sepium is a multipurpose tree native to Mesoamerica and possibly northern South America. The chemical composition of the hydrodistilled ...
Two new cellulolytic fungal species isolated from a 19th-century art collection
(2018)
The archive of the Universidad de Costa Rica maintains a nineteenth-century French collection of
drawings and lithographs in which the biodeterioration by fungi is rampant. Because of nutritional
conditions in which these ...
Actinoramide A Identified as a Potent Antimalarial from Titration-Based Screening of Marine Natural Product Extracts
(2015)
Methods to identify the bioactive diversity within natural product extracts (NPEs) continue to evolve. NPEs constitute complex mixtures of chemical substances varying in structure, composition, and abundance. NPEs can ...
Temperature and elemental sulfur shape microbial communities in two extremely acidic aquatic volcanic environments
(2021)
Aquatic environments of volcanic origin provide an exceptional opportunity to study the adaptations of microbial communities to early planet life conditions such as high temperatures, high metal concentrations, and low pH. ...
Fungal communities in feces of the frugivorous bat Ectophylla alba and its highly specialized Ficus colubrinae diet
(2022)
Background: Bats are important long-distance dispersers of many tropical plants, yet, by consuming fruits, they may
disperse not only the plant’s seeds, but also the mycobiota within those fruits. We characterized the ...
The clerodane diterpene casearin J induces apoptosis of T-ALL cells through SERCA inhibition, oxidative stress, and interference with Notch1 signaling
(2016-01-28)
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy that preferentially affects children and adolescents. Over 50% of human T-ALLs possess activating mutations of Notch1. The clerodane ...
Phylogenetic analysis of ITS data from endophytic fungi using massive parallel bayesian tree inference with exabayes
Análisis filogenético de secuencias ITS provenientes de hongos endófitos utilizando inferencia bayesiana paralela de árboles con exabayes
(2020-03-27)
Ecological studies of fungal communities have been favored thanks to the emergence and improvement of independent culture techniques that use the ITS region as a molecular marker. This has allowed a more accurate identification ...