Now showing items 1-3 of 3

    • Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis 

      Sidhu, Alpa; Miller, Justin R.; Tripathi, Ashootosh; Garshott, Danielle M.; Brownell, Amy L.; Chiego, Daniel J.; Arevang, Carl Johan; Zeng, Qinghua; Jackson, Leah C.; Bechler, Shelby A.; Callaghan, Michael U.; Yoo, George H.; Sethi, Seema; Lin, Ho-Sheng; Callaghan, Joseph H.; Tamayo Castillo, Giselle; Sherman, David H.; Kaufman, Randal J.; Fribley, Andrew M. (2015)
      Oral squamous cell carcinoma (OSCC) is the most common cancer affecting the oral cavity, and US clinics will register about 30,000 new patients in 2015. Current treatment modalities include chemotherapy, surgery, and ...
    • Discovery of cahuitamycins as biofilm inhibitors derived from a convergent biosynthetic pathway 

      Park, Sung Ryeol; Tripathi, Ashootosh; Wu, Jianfeng; Schultz, Pamela J.; Yim, Isaiah; McQuade, Thomas J.; Yu, Fengan; Arevang, Carl Johan; Mensah, Abraham Y.; Tamayo Castillo, Giselle; Xi, Chuanwu; Sherman, David H. (2016-02-16)
      Pathogenic microorganisms often have the ability to attach to a surface, building a complex matrix where they colonize to form a biofilm. This cellular superstructure can display increased resistance to antibiotics and ...
    • Discovery of nicoyamycin A, an inhibitor of uropathogenic Escherichia coli growth in low iron environments 

      Mike, Laura A.; Tripathi, Ashootosh; Blankenship, Connor M.; Saluk, Alyssa; Schultz, Pamela J.; Tamayo Castillo, Giselle; Sherman, David H.; Mobley, Harry L. T. (2017)
      High-throughput screening and activity-guided purification identified nicoyamycin A, a natural product comprised of an uncommon 3-methyl-1,4-dioxane ring incorporated into a desferrioxamine-like backbone via a spiroaminal ...