Now showing items 1-10 of 10

    • Actinoramide A Identified as a Potent Antimalarial from Titration-Based Screening of Marine Natural Product Extracts 

      Cheng, Ken Chih-Chien; Cao, Shugeng; Raveh, Avi; MacArthur, Ryan; Dranchak, Patricia; Chlipala, George; Okoneski, Matthew T.; Guha, Rajarshi; Eastman, Richard T.; Yuan, Jing; Schultz, Pamela J.; Su, Xin-zhuan; Tamayo Castillo, Giselle; Matainaho, Teatulohi; Clardy, Jon; Sherman, David H.; Inglese, James (2015)
      Methods to identify the bioactive diversity within natural product extracts (NPEs) continue to evolve. NPEs constitute complex mixtures of chemical substances varying in structure, composition, and abundance. NPEs can ...
    • Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis 

      Sidhu, Alpa; Miller, Justin R.; Tripathi, Ashootosh; Garshott, Danielle M.; Brownell, Amy L.; Chiego, Daniel J.; Arevang, Carl Johan; Zeng, Qinghua; Jackson, Leah C.; Bechler, Shelby A.; Callaghan, Michael U.; Yoo, George H.; Sethi, Seema; Lin, Ho-Sheng; Callaghan, Joseph H.; Tamayo Castillo, Giselle; Sherman, David H.; Kaufman, Randal J.; Fribley, Andrew M. (2015)
      Oral squamous cell carcinoma (OSCC) is the most common cancer affecting the oral cavity, and US clinics will register about 30,000 new patients in 2015. Current treatment modalities include chemotherapy, surgery, and ...
    • Costa rican international cooperative biodiversity group: using insects and other arthropods in biodiversity prospecting 

      Sittenfeld Appel, Ana; Tamayo Castillo, Giselle; Nielsen Muñoz, Vanessa; Jiménez, Allan; Hurtado Hernández, Priscilla; Chinchilla Carmona, Misael; Guerrero Bermúdez, Olga Marta; Mora, María Auxiliadora; Rojas, Miguel; Blanco, Roger; Alvarado, Eugenio; Gutiérrez, José María; Janzen, Daniel Hunt (Pharmaceutical Biology 37(Supplement):55–68. 1999, 1999)
      This paper describes the Costa Rican International Collaborative Biodiversity Group (ICBG), which was designed to introduce insects and other arthropods as a source of pharmaceutical compounds, and to generate knowledge ...
    • Diketopiperazines from Costa Rican endolichenic fungus Colpoma sp. CR1465A 

      Lee, Seulah; Tamayo Castillo, Giselle; Pang, Changhyun; Clardy, Jon; Cao, Shugeng; Kim, Ki Hyun (2016-05-15)
      Three new diketopiperazines (1–3), cyclo(l-Pro-d-trans-Hyp) (1), cyclo(l-Pro-d-Glu) (2), and cyclo(d-Pro-d-Glu) (3) and five known diketopiperazines (4–8) were isolated from the endolichenic fungus Colpoma sp. CR1465A ...
    • Discovery of cahuitamycins as biofilm inhibitors derived from a convergent biosynthetic pathway 

      Park, Sung Ryeol; Tripathi, Ashootosh; Wu, Jianfeng; Schultz, Pamela J.; Yim, Isaiah; McQuade, Thomas J.; Yu, Fengan; Arevang, Carl Johan; Mensah, Abraham Y.; Tamayo Castillo, Giselle; Xi, Chuanwu; Sherman, David H. (2016-02-16)
      Pathogenic microorganisms often have the ability to attach to a surface, building a complex matrix where they colonize to form a biofilm. This cellular superstructure can display increased resistance to antibiotics and ...
    • Efecto de extractos de artrópodos sobre la multiplicación del Toxoplasma gondiidentro de macrófagos peritoneales de ratón 

      Chinchilla Carmona, Misael; Herrera Corrales, Marlen; Guerrero Bermúdez, Olga Marta; Jiménez Somarribas, Alberto; Tamayo Castillo, Giselle; Sittenfeld Appel, Ana; Nielsen Muñoz, Vanessa; Hurtado Hernández, Priscilla (Rev. Biol. Trop. 51(2): 317-320, 2003, 2003)
      Treatment of toxoplasmosis usually causes secondary effects. It is important to find active substances extracted from natural organisms. In this work we studied some arthropod extracts that have effect against Toxoplasma ...
    • Novel Lobophorins Inhibit Oral Cancer Cell Growth and Induce Atf4- and Chop-Dependent Cell Death in Murine Fibroblasts 

      Cruz, Patricia G.; Fribley, Andrew M.; Miller, Justin R.; Larsen, Martha J.; Schultz, Pamela J.; Jacob, Renju T.; Tamayo Castillo, Giselle; Kaufman, Randal J.; Sherman, David H. (2015-07-06)
      As part of the International Cooperative Biodiversity Groups (ICBG) Program, we were interested in identifying biologically active unfolded protein response (UPR) inducing compounds from marine microorganisms isolated from ...
    • Recolecta de artrópodos para prospección de la biodiversidad en el Área de Conservación Guanacaste, Costa Rica 

      Nielsen Muñoz, Vanessa; Hurtado Hernández, Priscilla; Janzen, Daniel Hunt; Tamayo Castillo, Giselle; Sittenfeld Appel, Ana (Revista de Biología Tropical 52(1): 119-132, 2004, 2004)
      This study describes the results and collection practices for obtaining arthropod samples to be studied as potential sources of new medicines in a bioprospecting effort. From 1994 to 1998, 1800 arthropod samples of 6-10 g ...
    • Richness of cultivable endophytic fungi along an altitudinal gradient in wet forests of Costa Rica 

      Rojas Jiménez, Keilor Osvaldo; Hernández Alfaro, Myriam; Blanco Salas, Jorge; Vargas, Luis Diego; Acosta Vargas, Luis Guillermo; Tamayo Castillo, Giselle (2016-04)
      We collected various plant species along an altitudinal gradient ranging from 400 to 2900 m in tropical wet forests of Costa Rica, isolated the associated endophytic fungi, and performed bioinformatic analyses to determine ...
    • Study of the diversity of culturable actinomycetes in the North Pacific and Caribbean coasts of Costa Rica 

      Solano Arias, Godofredo; Rojas Jiménez, Keilor Osvaldo; Jaspars, Marcel; Tamayo Castillo, Giselle (2009)
      In this study, 137 actinomycetes were isolated from subtidal marine sediments in the North Pacific and Caribbean coasts of Costa Rica. Bioinformatics analysis of the 16S rRNA gene sequences assigned the isolates to 15 ...