Listar Biología por autor "Schultz, Pamela J."

Mostrando ítems 1-4 de 4

    • Actinoramide A Identified as a Potent Antimalarial from Titration-Based Screening of Marine Natural Product Extracts 

      Cheng, Ken Chih-Chien; Cao, Shugeng; Raveh, Avi; MacArthur, Ryan; Dranchak, Patricia; Chlipala, George E.; Okoneski, Matthew T.; Guha, Rajarshi; Eastman, Richard T.; Yuan, Jing; Schultz, Pamela J.; Su, Xin-zhuan; Tamayo Castillo, Giselle; Matainaho, Teatulohi; Clardy, Jon; Sherman, David H.; Inglese, James (2015)
      Methods to identify the bioactive diversity within natural product extracts (NPEs) continue to evolve. NPEs constitute complex mixtures of chemical substances varying in structure, composition, and abundance. NPEs can ...

    • Discovery of cahuitamycins as biofilm inhibitors derived from a convergent biosynthetic pathway 

      Park, Sung Ryeol; Tripathi, Ashootosh; Wu, Jianfeng; Schultz, Pamela J.; Yim, Isaiah; McQuade, Thomas J.; Yu, Fengan; Arevang, Carl Johan; Mensah, Abraham Y.; Tamayo Castillo, Giselle; Xi, Chuanwu; Sherman, David H. (2016-02-16)
      Pathogenic microorganisms often have the ability to attach to a surface, building a complex matrix where they colonize to form a biofilm. This cellular superstructure can display increased resistance to antibiotics and ...

    • Discovery of nicoyamycin A, an inhibitor of uropathogenic Escherichia coli growth in low iron environments 

      Mike, Laura A.; Tripathi, Ashootosh; Blankenship, Connor M.; Saluk, Alyssa; Schultz, Pamela J.; Tamayo Castillo, Giselle; Sherman, David H.; Mobley, Harry L. T. (2017)
      High-throughput screening and activity-guided purification identified nicoyamycin A, a natural product comprised of an uncommon 3-methyl-1,4-dioxane ring incorporated into a desferrioxamine-like backbone via a spiroaminal ...

    • Novel Lobophorins Inhibit Oral Cancer Cell Growth and Induce Atf4- and Chop-Dependent Cell Death in Murine Fibroblasts 

      Cruz, Patricia G.; Fribley, Andrew M.; Miller, Justin R.; Larsen, Martha J.; Schultz, Pamela J.; Jacob, Renju T.; Tamayo Castillo, Giselle; Kaufman, Randal J.; Sherman, David H. (2015-07-06)
      As part of the International Cooperative Biodiversity Groups (ICBG) Program, we were interested in identifying biologically active unfolded protein response (UPR) inducing compounds from marine microorganisms isolated from ...