Anti-inflammatory and analgesic activities of the aqueous extracts of Margaritaria discoidea (Euphorbiaceae) stem bark in experimental animal models

Adedapo, Adeolu A.; Sofidiya, Margaret O.; Afolayan, Anthony Jide

dc.creator	Adedapo, Adeolu A.
dc.creator	Sofidiya, Margaret O.
dc.creator	Afolayan, Anthony Jide
dc.date	2008-11-20
dc.date.accessioned	2016-05-03T15:29:31Z
dc.date.available	2016-05-03T15:29:31Z
dc.identifier	http://revistas.ucr.ac.cr/index.php/rbt/article/view/5456
dc.identifier	10.15517/rbt.v57i4.5456
dc.identifier.uri	https://hdl.handle.net/10669/26674
dc.description	Margaritaria discoidea is a medicinal plant used for the treatment of various body pains in Central, Eastern and Southern Africa. The aqueous extract of its stem bark was investigated for its anti-inflammatory and analgesic activities in animal models. The extract at 50, 100 and 200mg/kg body weight reduced significantly the formation of oedema induced by carrageenan and histamine. In the acetic acid-induced writhing model, the extract had a good analgesic effect characterized by a reduction in the number of writhes when compared to the control. Similarly, the extract caused dose-dependent decrease of licking time and licking frequency in rats injected with 2.5% formalin. These results were also comparable to those of indomethacin, the reference drug used in this study. Acute toxicity test showed that the plant may be safe for pharmacological uses. This study has provided some justification for the folkloric use of the plant in several communities for conditions such as stomachache, pain and inflammations.	en-US
dc.format	application/pdf
dc.language	eng
dc.publisher	Universidad de Costa Rica	en-US
dc.rights	Copyright (c) 2014 International Journal of Tropical Biology and Conservation	en-US
dc.source	Revista de Biología Tropical/International Journal of Tropical Biology and Conservation; Vol. 57 (4) December 2009	en-US
dc.source	Revista de Biología Tropical/International Journal of Tropical Biology and Conservation; Vol. 57 (4) December 2009	es-ES
dc.source	Revista Biología Tropical; Vol. 57 (4) December 2009	pt-PT
dc.source	2215-2075
dc.source	0034-7744
dc.source	10.15517/rbt.v57i4
dc.title	Anti-inflammatory and analgesic activities of the aqueous extracts of Margaritaria discoidea (Euphorbiaceae) stem bark in experimental animal models	en-US
dc.title	Anti-inflammatory and analgesic activities of the aqueous extracts of Margaritaria discoidea (Euphorbiaceae) stem bark in experimental animal models	es-ES
dc.type	artículo original
dc.coverage	CRC	en-US

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