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Predominance of carbapenem-resistant Pseudomonas aeruginosa isolates carrying blaIMP and blaVIM metallo-β-lactamases in a major hospital in Costa Rica
(2015)
This study aimed to assess the molecular basis of the resistance to carbapenems in clinical isolates of Pseudomonas aeruginosa recovered from a tertiary-level health facility in San José, Costa Rica. A total of 198 ...
Comparative study on coagulant, defibrinating, fibrinolytic and fibrinogenolytic activities of Costa Rican crotaline snake venoms and their neutralization by a polyvalent antivenom
(1989)
The coagulant, defibrinating, fibrino lytic and fibrinogenolytic activities of venoms from ten species of Costa Rican crotaline snakes were studied, together with the neutralization of these effects by a polyvalent antivenom. ...
Characterization of 'basparin A,' a prothrombin-activating metalloproteinase, from the venom of the snake Bothrops asper that inhibits platelet aggregation and induces defibrination and thrombosis
(2003-10)
A prothrombin activator, named ‘basparin A,’ was isolated from the venom of the crotaline snake Bothrops asper, the species responsible for the majority of snakebite cases in Central America. It is an acidic (pI 5.4), 70 ...
Sphingolipid pathway as a biosensor of cancer chemosensitivity: a proof of principle
La vía de los esfingolípidos como biosensor de la quimiosensibilidad al cáncer: Una prueba de principio
A via dos esfingolipídeos como biossensor da quimiossensibilidade do câncer: Uma prova de princípio
(2022-12)
Cancer is a complex genetic disease with reduced treatment alternatives due to tumor heterogeneity and
drug multiresistance emergence. The sphingolipid (SL) metabolic pathway integrates different responses
of cellular ...
Combined venomics, venom gland transcriptomics, bioactivities, and antivenomics of two Bothrops jararaca populations from geographic isolated regions within the Brazilian Atlantic rainforest
(2016-03-01)
Bothrops jararaca is a slender and semi-arboreal medically relevant pit viper species endemic to tropical and subtropical forests in southern Brazil, Paraguay, and northern Argentina (Misiones). Within its geographic range, ...
Exploring the venom of the forest cobra snake: Toxicovenomics and antivenom profiling of Naja melanoleuca
(2017-01-06)
A toxicovenomic analysis of the venomof the forest cobra, N. melanoleuca,was performed, revealing the presence
of a total of 52 proteins by proteomics analysis. The most abundant proteins belong to the three-finger ...
Two-dimensional gel electrophoresis (2D-GE) image analysis based on CellProfiler: Pseudomonas aeruginosa AG1 as model
(2020)
Two-dimensional gel electrophoresis (2D-GE) is an indispensable technique for the study of proteomes of biological systems,
providing an assessment of changes in protein abundance under various experimental conditions. ...
Acanthamoeba genotype T4 keratitis in a patient with Thygeson’s superficial punctate keratitis
Queratitis por Acanthamoeba genotipo T4 en un paciente con queratitis punteada de Thygeson
(2017-01)
A case of amoebic keratitis due to Acanthamoeba genotype T4 is reported. The patient is a 74-year old
woman with Thygeson’s superficial punctate keratitis. Corneal scrapings were employed for the diagnosis, which included ...