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Plan para la implementación de tetanalgesia como método de analgesia no farmacológica en procedimientos de extracción sanguínea en el Laboratorio Clínico del Hospital Nacional de Niños de la Caja Costarricense de Seguro Social
(2023)
Los recién nacidos y lactantes pequeños son capaces de experimentar dolor desde la semana veinticinco de edad gestacional. Recientemente, se han estudiado mecanismos alternativos a los fármacos analgésicos que estimulan ...
Unexpected Functional Divergence of Bat Influenza Virus NS1 Proteins
(2018-02-12)
Recently, two influenza A virus (FLUAV) genomes were identified in Central and South American bats. These sequences exhibit notable divergence from classical FLUAV counterparts, and functionally, bat FLUAV glycoproteins ...
Structural and functional characterization of BnSP-7, a lysine-49 myotoxic phospholipase A2 homologue from Bothrops neuwiedi pauloensis venom
(2000)
BnSP-7, a Lys49 myotoxic phospholipase A2 homologue
from Bothrops neuwiedi pauloensis venom, was
structurally and functionally characterized. Several
biological activities were assayed and compared with
those of the ...
Understanding and confronting snakebite envenoming: The harvest of cooperation
(2016-01)
During 45 years, the Instituto Clodomiro Picado (ICP, University of Costa Rica) has developed an ambitious scientific, technological, productive, and social program aimed at providing a better understanding of snakes and ...
Myotoxic and cytolytic activities of dimeric Lys49 phospholipase A2 homologues are reduced, but not abolished, by a pH-induced dissociation
(2005-09-01)
Lys49 phospholipase A2 (PLA2) homologues are myotoxic proteins devoid of catalytic activity. Their toxic determinants map to the C-terminal region 115–129, which plays an effector role in membrane damage. The dimeric state ...
Venenos de serpientes de la familia Viperidae en América: Bioquímica y fisiopatología.
(2011)
Se muestra una perspectiva general de las características bioquímicas de los principales tipos de toxinas
presentes en los venenos de vipéridos americanos y la fisiopatología de estos envenenamientos. En la preparación ...
In vitro discovery of a human monoclonal antibody that neutralizes lethality of cobra snake venom.
(2022)
The monocled cobra (Naja kaouthia) is among the most feared snakes in Southeast Asia due to its toxicity, which is predominantly derived from long-chain α-neurotoxins. The only specific treatment for snakebite envenoming ...
Antivenomic Assessment of the Immunological Reactivity of EchiTAb-Plus-ICP, an Antivenom for the Treatment of Snakebite Envenoming in Sub-Saharan Africa
(2010)
The immunoreactivity of EchiTAb-Plus-ICP, an antivenom developed for the treatment of snakebite envenoming in sub-Saharan Africa, to venoms of seven Echis and Bitis species, was assessed by “antivenomics.” This proteomic ...
Divergent functional profiles of acidic and basic phospholipases A2 in the venom of the snake Porthidium lansbergii lansbergii
(2016-09-01)
The Lansberg’s hognose pitviper, Porthidium lansbergii lansbergii, inhabits northern Colombia. A recent
proteomic characterization of its venom (J. Proteomics [2015] 114, 287e299) revealed the presence of
phospholipases ...