Buscar
Mostrando ítems 1-10 de 21
Dengue Virus Infection of Primary Human Smooth Muscle Cells
(2018-11-05)
Dengue virus (DENV) infection of humans is presently the most important arthropod-borne viral global threat, for which no suitable or reliable animal model exists. Reports addressing the effect of DENV on vascular components ...
SARS-CoV-2 genomic surveillance in Costa Rica: Evidence of a divergent population and an increased detection of a spike T1117I mutation
(2021)
Genome sequencing is a key strategy in the surveillance of SARS-CoV-2, the virus responsible for the COVID-19 pandemic. Latin America is the hardest-hit region of the world, accumulating almost 20% of COVID-19 cases ...
Specific Mutations in the PB2 Protein of Influenza A Virus Compensate for the Lack of Efficient Interferon Antagonism of the NS1 Protein of Bat Influenza A-Like Viruses
(2018-03-14)
Recently, two new influenza A-like viruses have been discovered in bats, A/little yellow-shouldered bat/Guatemala/060/2010 (HL17NL10) and A/flat-faced bat/Peru/033/2010 (HL18NL11). The hemagglutinin (HA)-like (HL) and ...
Heterologous hyperimmune polyclonal antibodies against SARS-COV-2: A broad coverage, affordable, and scalable potential immunotherapy for Covid-19
(2021-09)
The emergence and dissemination of the severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) and the resulting COVID-19 pandemic triggered a global public health crisis.
Although several SARS-CoV-2 vaccines have ...
Development of an instrument-free and low-cost ELISA dot-blot test to detect antibodies against SARS-CoV-2
(2023-02)
Most laboratory tests to detect the presence of anti-SARS-CoV-2 antibodies use ELISA or CLIA; however, equipment for these immunoassays is unavailable in many areas of low- and middle-income countries. Rapid lateral flow ...
Highly individual patterns of virus‑immune IgG effector responses in humans
(2016-05-18)
t IgG responses are fundamental to adaptive
immunity and document immunological memory of previous
pathogen encounter. While specific antigen recognition
is mediated by the variable F(ab′)2 domain of IgG, various
effector ...
Pathogenic potential of a Costa Rican strain of ‘Candidatus Rickettsia amblyommii’ in guinea pigs (Cavia porcellus) and protective immunity against Rickettsia rickettsii
(2015-07)
‘Candidatus Rickettsia amblyommii’ is a spotted fever group rickettsia that is not considered pathogenic, although there is serologic evidence of possible infection in animals and humans. The aim of this study was to ...
Síndrome Respiratorio de Medio Oriente causado por un coronavirus y el Hajj: ¿potencial para una emergencia internacional?
Middle East Respiratory Syndrome caused by a coronavirus and Hajj: an international health threat?
(2014)
La epidemiología de enfermedades infecciosas en eventos de concentración masiva requiere de un amplio planeamiento y control por parte de los centros de salud de cada país involucrado. El Síndrome Respiratorio de Medio ...
Chikungunya: un virus que nos acecha
(2015-06-01)
El virus chikungunya representa una amenaza para Costa Rica. Este arbovirus ha sido introducido
al continente americano desde finales de 2013. Debido a sus características epidemiológicas y
virológicas, y a la presencia ...
In Vitro Inhibition of Zika Virus Replication with Amantadine and Rimantadine Hydrochlorides
(2021-09-15)
Zika virus (ZIKV) is a mosquito-borne flavivirus in which human infection became relevant
during recent outbreaks in Latin America due to its unrecognized association with fetal neurological
disorders. Currently, there ...