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Depletion of complement enhances the clearance of Brucella abortus in mice
(2018)
Brucellosis is a bacterial disease of animals and humans. Brucella abortus
barely activates the innate immune system at the onset of infection, and this
bacterium is resistant to the microbicidal action of complement. ...
A Clostridium difficile Lineage Endemic to Costa Rican Hospitals Is Multidrug Resistant by Acquisition of Chromosomal Mutations and Novel Mobile Genetic Elements
(2017-01)
The antimicrobial resistance (AMR) rates and levels recorded for Clostridium difficile are on the rise. This study reports the nature, levels, diversity, and genomic context of the antimicrobial resistance of human C. ...
Brucella neotomae Infection in Humans, Costa Rica
(2017-06)
Several species of Brucella are known to be zoonotic, but B. neotomae infection has been thought to be limited to wood rats. In 2008 and 2011, however, B. neotomae was isolated from cerebrospinal fluid of 2 men with ...
Brucella abortus Strain 2308 Wisconsin Genome: Importance of the Definition of Reference Strains
(2016-09-29)
Brucellosis is a bacterial infectious disease affecting a wide range of mammals and a
neglected zoonosis caused by species of the genetically homogenous genus Brucella.
As in most studies on bacterial diseases, research ...
Intracellular passage triggers a molecular response in that increases its infectiousness
(2021)
Brucella abortus is a facultative extracellular-intracellular pathogen that encounters a diversity of environments within the host cell. We report that bacteria extracted from infected cells at late stages (48 h post-infection) ...
Emergence of an Outbreak-Associated Clostridium difficile Variant with Increased Virulence
(2015-04)
The prevalence of Clostridium difficile infections has increased due to the emergence of epidemic variants from diverse genetic lineages. Here we describe the emergence of a novel variant during an outbreak in a Costa Rican ...
Senses the Intracellular Environment through the BvrR/BvrS Two-Component System, Which Allows To Adapt to Its Replicative Niche
(2018-03-22)
Brucella abortus is a facultative extracellular-intracellular pathogen belonging to a group of Alphaproteobacteria that establishes close interactions with animal cells. This bacterium enters host cells in a membrane-bound ...
Brucellosis caused by the wood rat pathogen Brucella neotomae: two case reports
(2017-12-19)
Background: Brucellosis is a chronic bacterial disease caused by members of the genus Brucella. Among the
classical species stands Brucella neotomae, until now, a pathogen limited to wood rats. However, we have identified
two ...
Phenotypes controlled by the Brucella abortus two component system BvrR/BvrS are differentially impacted by BvrR phosphorylation
(2023-04)
Brucella abortus is a zoonotic pathogen whose virulence depends on its ability
to survive intracellularly at the endoplasmic reticulum derived compartment.
The two-component system BvrR/BvrS (BvrRS) is essential for ...
Virulent Brucella nosferati infecting Desmodus rotundus has emerging potential due to the broad foraging range of its bat host for humans and wild and domestic animals
(2023)
Desmodus rotundus, vampire bats, transmit dangerous infections, and brucellosis is a hazardous zoonotic disease, two adversities that coexist in the subtropical and tropical areas of the American continent. Here, we report ...