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Susceptibilidad de Trypanosoma cruzi a diferentes venenos de serpientes de Costa Rica
Susceptibility of Trypanosoma cruzi to different Costa Rican snake venoms
Se evaluaron los efectos tóxicos de los venenos de cinco serpientes costarricenses en cuanto a su capacidad tripanocida contra dos cepas de Trypanosoma cruzi y sus efectos en cuanto a los mecanismos de muerte celular. ...
Ability of fucoidan to prevent muscle necrosis induced by snake venom myotoxins: comparison of high- and low-molecular weight fractions
Fucoidan, a natural polysaccharide extracted from brown seaweed, inhibits the myotoxic phospholipases A2 present in the venoms of crotalid snakes. This study evaluated the influence of molecular weight on the ability of ...
Differential susceptibility of C2C12 myoblasts and myotubes to group II phospholipase A2 myotoxins from crotalid snake venoms
Group II phospholipase A2 (PLA2) myotoxins isolated from Viperidae/Crotalidae snake venoms induce a rapid cytolytic effect upon diverse cell types in vitro. Previous studies suggested that this effect could be more ...
Catalytically inactive phospholipase A2 homologue binds to vascular endothelial growth factor receptor-2 via C-terminal loop region
VEGF (vascular endothelial growth factor) regulates neovascularization through binding to its receptorKDR(kinase insert domaincontaining receptor; VEGF receptor-2). We recently identified a catalytically inactive PLA2 ...
Human heterophilic antibodies against equine immunoglobulins: assessment of their role in the early adverse reactions to antivenom administration
The presence of human heterophilic antibodies against horse immunoglobulins (HHA-HI) was determined by ELISA in sera from healthy volunteers and from patients who received equine antivenom for therapy of snake bite ...
Venom, venomics, antivenomics
Venoms comprise mixtures of peptides and proteins tailored by Natural Selection to act on vital systems of the prey or victim. Here we review our proteomic protocols for uncoiling the composition, immunological profile, ...
Synthetic peptides derived from the C-terminal region of Lys49 phospholipase A2 homologues from Viperidae snake venoms: biomimetic activities and potential applications
Lys49-phospholipase A2 homologues constitute a large family of toxins present in the venoms of viperid snake species, which despite lacking catalytic activity, cause significant skeletal muscle necrosis. The main structural ...
Mortality by Hymenoptera stings in Costa Rica, 1985-2006
Mortalidad por picaduras de himenópteros en Costa Rica, 1985–2006
Objective. To analyze mortality due to Hymenoptera stings in Costa Rica during 1985–2006. Methods. Records of deaths due to Hymenoptera stings in 1985–2006 were retrieved from Instituto Nacional de Estadística y Censos ...
Screening for target toxins of the antiophidic protein DM64 through a gel-based interactomics approach
DM64 is a glycosylated protein with antivenomactivity isolated fromthe serum of the opossumDidelphis aurita. It binds non-covalently to myotoxins I (Asp49) and II (Lys49) from Bothrops asper venom and inhibits their myotoxic ...
Dengue in Costa Rica: the gap in local scientific research
Dengue en Costa Rica: la brecha en la investigación científica local
Globalization has affected the reemergence of infectious diseases, with increased human travel and trade facilitating the introduction of diseases into new areas and the resurgence of diseases that had been eliminated in ...