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First crotoxin-like phospholipase A2 complex from a New World non-rattlesnake species: Nigroviriditoxin, from the arboreal Neotropical snake Bothriechis nigroviridis 

Lomonte, Bruno; Mora Obando, Diana; Fernández Ulate, Julián; Sanz, Libia; Pla Ferrer, Davinia; Gutiérrez, José María; Calvete Chornet, Juan José (Toxicon vol 93:144–154, 2015-01)
Bothriechis nigroviridis is an arboreal Neotropical pitviper found in Costa Rica and Panam a. A previous proteomic profiling of its venom revealed the presence of proteins with homology to the A and B subunits of ...

Pathological changes induced by BaH1, a hemorrhagic proteinase isolated from Bothrops asper (Terciopelo) snake venom, on mouse capillary blood vessels 

Moreira Carmona, Lisela; Borkow, Gadi; Ovadia, Michael; Gutiérrez, José María (1994-08)
The pathological changes induced in capillaries by BaH1, a hemorrhagic metalloproteinase isolated from the venom of Bothrops asper, were studied after i.m. injection in mouse gastrocnemius. Hemorrhage was observed ...

Calcium imaging of muscle cells treated with snake myotoxins reveals toxin synergism and presence of acceptors 

Cintra Francischinelli, Mariana; Pizzo, Paola; Rodrigues Simioni, Lea; Ponce Soto, Luis Alberto; Rossetto, O.; Lomonte, Bruno; Gutiérrez, José María; Pozzan, T.; Montecucco, Cesare (2009-04-17)
Snake myotoxins have a great impact on human health worldwide. Most of them adopt a phospholipase A2 fold and occur in two forms which often co-exist in the same venom: the Asp49 toxins hydrolyse phospholipids, whilst Lys49 ...
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Poor regenerative outcome after skeletal muscle necrosis induced by Bothrops asper venom: alterations in microvasculature and nerves 

Hernández, Rosario; Cabalceta, Carmen; Saravia Otten, Patricia; Chaves, Alessandra; Gutiérrez, José María; Rucavado Romero, Alexandra (PLoS ONE 6(5): e19834, 2011-05-24)
Background: Viperid snakebite envenoming is characterized by prominent local tissue damage, including muscle necrosis. A frequent outcome of such local pathology is deficient skeletal muscle regeneration, which causes ...
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Phospholipases a2 from Viperidae snakes: Differences in membranotropic activity between enzymatically active toxin and its inactive isoforms 

Ghazaryan, Narine A.; Ghulikyan, Lusine; Kishmiryan, Arsen; Andreeva, Tatyana V.; Utkin, Yuri N.; Tsetlin, Victor I.; Lomonte, Bruno; Ayvazyan, Naira M. (Biochimica et Biophysica Acta - Biomembranes vol 1848: 463–468, 2015-02)
We describe the interaction of various phospholipases A2 (PLA2) from snake venoms of the family Viperidae (Macrovipera lebetina obtusa, Vipera ursinii renardi, Bothrops asper) with giant unilamellar vesicles (GUVs) composed ...
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A eficácia do antiveneno botrópico-crotálico na neutralização das principais atividades do veneno de Bothrops jararacussu 

Dos Santos, María Cristina; Gonçalves, Luís Roberto de Camargo; Fortes Dias, Consuelo L.; Cury, Yara; Gutiérrez, José María; Furtado, María de Fátima (1992)
Myonecrosis is one of the effects of Bothrops jararacussu venom, from which a myotoxin was isolated showing structural homology to phospholipase A2 (PLA2), but without enzimatic activity. Such myotoxic activity is also ...

Snake venomics and antivenomics of Bothrops colombiensis, a medically important pitviper of the Bothrops atrox-asper complex endemic to Venezuela: Contributing to its taxonomy and snakebite management 

Calvete Chornet, Juan José; Borges, Adolfo; Segura Ruiz, Álvaro; Flores Díaz, Marietta; Alape Girón, Alberto; Gutiérrez, José María; Diez, Nardy; De Sousa, Leonardo; Kiriakos, Demetrio; Sánchez, Eladio; Faks, José G.; Escolano, José; Sanz, Libia (2009-03-06)
The taxonomic status of the medically important pitviper of the Bothrops atrox-asper complex endemic to Venezuela, which has been classified as Bothrops colombiensis, remains incertae cedis. To help resolving this question, ...
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N-Formyl-Perosamine Surface Homopolysaccharides Hinder the Recognition of Brucella abortus by Mouse Neutrophils 

Mora Cartín, Ricardo; Chacón Díaz, Carlos; Gutiérrez Jiménez, Cristina; Gurdián Murillo, Stephany; Lomonte, Bruno; Chaves Olarte, Esteban; Barquero Calvo, Elías; Moreno Robles, Edgardo (2016-06)
Brucella abortus is an intracellular pathogen of monocytes, macrophages, dendritic cells, and placental trophoblasts. This bacterium causes a chronic disease in bovines and in humans. In these hosts, the bacterium also ...

Comparison between IgG and F(ab′)2 polyvalent antivenoms: neutralization of systemic effects induced by Bothrops asper venom in mice, extravasation to muscle tissue, and potential for induction of adverse reactions 

León Montero, Guillermo; Monge Monge, María; Rojas Umaña, Ermila; Lomonte, Bruno; Gutiérrez, José María (2001-06)
Whole IgG and F(ab′)2 equine-derived polyvalent (Crotalinae) antivenoms, prepared from the same batch of hyperimmune plasma, were compared in terms of neutralization of the lethal and defibrinating activities induced by ...
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A biocomputational platform for the automated construction of large-scale mathematical models of miRNA-transcription factor networks for studies on gene dosage compensation 

Acón, Man Sai; Siles Canales, Francisco; Mora Rodríguez, Rodrigo Antonio (2016-11-09)
Cancer complexity and resistance is mediated by cell-to-cell heterogeneity, which is the consequence of the enormous instability of its genetic material. It is unknown how cancer cells are able to withstand the effects ...
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AuthorGutiérrez, José María (372)Lomonte, Bruno (248)Rucavado Romero, Alexandra (66)Angulo Ugalde, Yamileth (64)Calvete Chornet, Juan José (59)León Montero, Guillermo (54)Troyo Rodríguez, Adriana (41)Sanz, Libia (40)Calderón Arguedas, Ólger (38)Herrera Vega, María (35)... View MoreType
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