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Venom, venomics, antivenomics 

Calvete Chornet, Juan José; Sanz, Libia; Angulo Ugalde, Yamileth; Lomonte, Bruno; Gutiérrez, José María (2009)
Venoms comprise mixtures of peptides and proteins tailored by Natural Selection to act on vital systems of the prey or victim. Here we review our proteomic protocols for uncoiling the composition, immunological profile, ...

Snake venomics and antivenomics of Bothrops atrox venoms from Colombia and the Amazon regions of Brazil, Perú and Ecuador suggest the occurrence of geographic variation of venom phenotype by a trend towards paedomorphism 

Núñez Rangel, Vitelbina; Cid, Pedro; Sanz, Libia; De La Torre, Pilar; Angulo Ugalde, Yamileth; Lomonte, Bruno; Gutiérrez, José María; Calvete Chornet, Juan José (2009-11-02)
The venom proteomes of Bothrops atrox from Colombia, Brazil, Ecuador, and Perú were characterized using venomic and antivenomic strategies. Our results evidence the existence of two geographically differentiated venom ...

Impact of Regional Variation in Bothrops asper Snake Venom on the Design of Antivenoms: Integrating Antivenomics and Neutralization Approaches 

Gutiérrez, José María; Sanz, Libia; Flores Díaz, Marietta; Figueroa, Lucía; Madrigal Villalobos, Marvin; Herrera Vega, María; Villalta Arrieta, Mauren; León Montero, Guillermo; Estrada Umaña, Ricardo; Borges, Adolfo; Alape Girón, Alberto; Calvete Chornet, Juan José (2010-10-21)
Intraspecific snake venom variations have implications in the preparation of venom pools for the generation of antivenoms. The impact of such variation in the cross-reactivity of antivenoms against Bothrops asper venom was ...

Snake venomics of Lachesis muta rhombeata and genus-wide antivenomics assessment of the paraspecific immunoreactivity of two antivenoms evidence the high compositional and immunological conservation across Lachesis 

Pla Ferrer, Davinia; Sanz, Libia; Molina Sánchez, Pedro; Zorita, Virginia; Madrigal Villalobos, Marvin; Flores Díaz, Marietta; Alape Girón, Alberto; Núñez Rangel, Vitelbina; Andrés, Vicente; Gutiérrez, José María; Calvete Chornet, Juan José (2013-08-26)
We report the proteomic analysis of the Atlantic bushmaster, Lachesis muta rhombeata, from Brazil. Along with previous characterization of the venom proteomes of L. stenophrys (Costa Rica), L. melanocephala (Costa Rica), ...

Snake population venomics and antivenomics of Bothrops atrox: Paedomorphism along its transamazonian dispersal and implications of geographic venom variability on snakebite management 

Calvete Chornet, Juan José; Sanz, Libia; Pérez, Alicia; Borges, Adolfo; Vargas, Alba M.; Lomonte, Bruno; Angulo Ugalde, Yamileth; Gutiérrez, José María; Chalkidis, Hipócrates M.; Mourão, Rosa H.V.; Furtado, María de Fátima; Moura Da Silva, Ana M. (2011-04-11)
We describe two geographically differentiated venom phenotypes across the wide distribution range of Bothrops atrox, from the Colombian Magdalena Medio Valley through Puerto Ayacucho and El Paují, in the Venezuelan States ...

Snake Venomics of African Spitting Cobras: Toxin Composition and Assessment of Congeneric Cross-Reactivity of the Pan-African EchiTAb-Plus-ICP Antivenom by Antivenomics and Neutralization Approaches 

Petras, Daniel; Sanz, Libia; Segura Ruiz, Álvaro; Herrera Vega, María; Villalta Arrieta, Mauren; Solano, Daniela; Vargas Arroyo, Mariángela; León Montero, Guillermo; Warrell, David A.; Theakston, R. David G.; Harrison, Robert A.; Durfa, Nandul; Nasidi, Abdulsalami; Gutiérrez, José María; Calvete Chornet, Juan José (2011)
Venomic analysis of the venoms of Naja nigricollis, N. katiensis, N. nubiae, N. mossambica, and N. pallida revealed similar compositional trends. The high content of cytotoxins and PLA2s may account for the extensive tissue ...

Understanding structural and functional aspects of PII snake venom metalloproteinases: Characterization of BlatH1, a hemorrhagic dimeric enzyme from the venom of Bothriechis lateralis 

Camacho Umaña, Erika; Villalobos Chacón, Eva; Sanz, Libia; Pérez, Alicia; Escalante Muñoz, Teresa; Lomonte, Bruno; Calvete Chornet, Juan José; Gutiérrez, José María; Rucavado Romero, Alexandra (2014-06)
A new homodimeric PII metalloproteinase, named BlatH1, was purified from the venom of the Central American arboreal viperid snake Bothriechis lateralis by a combination of anion-exchange chromatography, hydrophobic interaction ...

Venomic and antivenomic analyses of the Central American coral snake, Micrurus nigrocinctus (Elapidae) 

Fernández Ulate, Julián; Alape Girón, Alberto; Angulo Ugalde, Yamileth; Sanz, Libia; Gutiérrez, José María; Calvete Chornet, Juan José; Lomonte, Bruno (2011-01-31)
The proteome of the venom of Micrurus nigrocinctus (Central American coral snake) was analyzed by a “venomics” approach. Nearly 50 venom peaks were resolved by RP-HPLC, revealing a complex protein composition. Comparative ...

Assessing the preclinical efficacy of antivenoms: From the lethality neutralization assay to antivenomics 

Gutiérrez, José María; Solano Trejos, María Gabriela; Pla Ferrer, Davinia; Herrera Vega, María; Segura Ruiz, Álvaro; Villalta Arrieta, Mauren; Vargas Arroyo, Mariángela; Sanz, Libia; Lomonte, Bruno; Calvete Chornet, Juan José; León Montero, Guillermo (2013-07)
The assessment of the capacity of antivenoms to neutralize the lethal activity of snake venoms is the gold standard in the preclinical analysis of antivenom efficacy, and is routinely performed by manufacturers and quality ...
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Integrated “omics” profiling indicates that miRNAs are modulators of the ontogenetic venom composition shift in the Central American rattlesnake, Crotalus simus simus 

Durban, Jordi; Pérez, Alicia; Sanz, Libia; Gómez Argüello, Aarón; Bonilla Murillo, Fabián; Rodríguez Arguedas, Santos; Chacón Gutiérrez, Danilo; Sasa Marín, Mahmood; Angulo Ugalde, Yamileth; Gutiérrez, José María; Calvete Chornet, Juan José (2013)
Background Understanding the processes that drive the evolution of snake venom is a topic of great research interest in molecular and evolutionary toxinology. Recent studies suggest that ontogenetic changes in venom ...
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AuthorCalvete Chornet, Juan José (44)
Sanz, Libia (44)
Gutiérrez, José María (40)Lomonte, Bruno (31)Angulo Ugalde, Yamileth (17)Pla Ferrer, Davinia (17)Fernández Ulate, Julián (12)Alape Girón, Alberto (8)Pérez, Alicia (8)León Montero, Guillermo (7)... View MoreTypeinfo:eu-repo/semantics/article (42)artículo científico (40)capítulo de libro (1)info:eu-repo/semantics/bookPart (1)info:eu-repo/semantics/preprint (1)Preprint (1)ProcedenceVicerrectoría de Investigación (44)Vicerrectoría de Docencia (4)... View MoreHas File(s)Yes (44)

  • Repositorios universitarios

  • Repositorio del SIBDI-UCR
  • Biblioteca Digital del CIICLA
  • Repositorio Documental Rafael Obregón Loría (CIHAC)
  • Biblioteca Digital Carlos Melendez (CIHAC)
  • Repositorio de Fotografías
  • Colección de videos de UPA-VAS
  • Sitios recomendados

  • Buscador regional de LA Referencia
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  • Directory of Open Access Journals (DOAJ)
  • Redalyc
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  • @Ciencia_UCR
  • Sobre Kérwá
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  • Políticas
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Universidad de Costa Rica