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Human heterophilic antibodies against equine immunoglobulins: assessment of their role in the early adverse reactions to antivenom administration 

León Montero, Guillermo; Segura Ruiz, Álvaro; Herrera Vega, María; Otero Patiño, Rafael; França, Francisco Oscar; Barbaro, Katia Cristina; Cardoso, João Luiz Costa; Wen, Fan Hui; de Medeiros, Carlos Roberto; Prado, José Carlos Lopes; Malaque, Ceila María Sant’Ana; Lomonte, Bruno; Gutiérrez, José María (2008)
The presence of human heterophilic antibodies against horse immunoglobulins (HHA-HI) was determined by ELISA in sera from healthy volunteers and from patients who received equine antivenom for therapy of snake bite ...
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Método para la producción de formulaciones inyectables de productos proteicos hemoderivados y productos obtenidos utilizando dicho método 

Segura Ruiz, Álvaro; Vargas Arroyo, Mariángela; León Montero, Guillermo; Angulo Ugalde, Yamileth; Villalta Arrieta, Mauren; Herrera Vega, María (2011-04-08)
The invention relates to a method for producing injectable pharmaceutical formulations of blood-derived protein materials, including the steps of fractioning the source material in a polymer/salt aqueous two-phasesystem ...
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Preclinical evaluation of caprylic-acid fractionated IgG antivenom for the treatment of taipan (Oxyuranus scutellatus) envneoming in Papua New Guinea 

Vargas Arroyo, Mariángela; Segura Ruiz, Álvaro; Herrera Vega, María; Villalta Arrieta, Mauren; Estrada Umaña, Ricardo; Cerdas Solís, Maykel; Paiva, Owen K.; Matainaho, Teatulohi; Jensen, Simon D.; Winkel, Kenneth D.; León Montero, Guillermo; Gutiérrez, José María; Williams, David J. (PLoS Neglected Tropical Diseases 5 (5) e1144, 2011-05-17)
Background: Snake bite is a common medical emergency in Papua New Guinea (PNG). The taipan, Oxyuranus scutellatus, inflicts a large number of bites that, in the absence of antivenom therapy, result in high mortality. ...

Comparison of the effect of Crotalus simus and Crotalus durissus ruruima venoms on the equine antibody response towards Bothrops asper venom: Implications for the production of polyspecific snake antivenoms 

Dos Santos, María Cristina; Arroyo Portilla, Cynthia; Solano Rojas, Sergio; Herrera Vega, María; Villalta Arrieta, Mauren; Segura Ruiz, Álvaro; Estrada Umaña, Ricardo; Gutiérrez, José María; León Montero, Guillermo (2011-02)
Antivenoms are preparations of immunoglobulins purified from the plasma of animals immunized with snake venoms. Depending on the number of venoms used during the immunization, antivenoms can be monospecific (if venom from ...

Impact of Regional Variation in Bothrops asper Snake Venom on the Design of Antivenoms: Integrating Antivenomics and Neutralization Approaches 

Gutiérrez, José María; Sanz, Libia; Flores Díaz, Marietta; Figueroa, Lucía; Madrigal Villalobos, Marvin; Herrera Vega, María; Villalta Arrieta, Mauren; León Montero, Guillermo; Estrada Umaña, Ricardo; Borges, Adolfo; Alape Girón, Alberto; Calvete Chornet, Juan José (2010-10-21)
Intraspecific snake venom variations have implications in the preparation of venom pools for the generation of antivenoms. The impact of such variation in the cross-reactivity of antivenoms against Bothrops asper venom was ...

Proteomic and toxinological characterization of the venom of the South African Ringhals cobra Hemachatus haemachatus 

Sánchez Brenes, Andrés; Herrera Vega, María; Villalta Arrieta, Mauren; Solano, Daniela; Segura Ruiz, Álvaro; Lomonte, Bruno; Gutiérrez, José María; León Montero, Guillermo; Vargas Arroyo, Mariángela (2018-06)
The protein composition and toxinological profile of the venom of the African spitting elapid Hemachatus haemachatus (Ringhals) were characterized by bottom-up proteomics and functional in vitro and in vivo assays. Venom ...

Snake Venomics of African Spitting Cobras: Toxin Composition and Assessment of Congeneric Cross-Reactivity of the Pan-African EchiTAb-Plus-ICP Antivenom by Antivenomics and Neutralization Approaches 

Petras, Daniel; Sanz, Libia; Segura Ruiz, Álvaro; Herrera Vega, María; Villalta Arrieta, Mauren; Solano, Daniela; Vargas Arroyo, Mariángela; León Montero, Guillermo; Warrell, David A.; Theakston, R. David G.; Harrison, Robert A.; Durfa, Nandul; Nasidi, Abdulsalami; Gutiérrez, José María; Calvete Chornet, Juan José (2011)
Venomic analysis of the venoms of Naja nigricollis, N. katiensis, N. nubiae, N. mossambica, and N. pallida revealed similar compositional trends. The high content of cytotoxins and PLA2s may account for the extensive tissue ...

Comparison of the adjuvant activity of aluminum hydroxide and calcium phosphate on the antibody response towards Bothrops asper snake venom 

Olmedo, Hidekel; Herrera Vega, María; Rojas Sánchez, Leonardo; Villalta Arrieta, Mauren; Vargas Arroyo, Mariángela; Leiguez, Elbio; Teixeira, Catarina de Fátima; Estrada Umaña, Ricardo; Gutiérrez, José María; León Montero, Guillermo; Montero Villalobos, Mavis Lili (2014)
The adjuvanticity of aluminum hydroxide and calcium phosphate on the antibody response in mice towards the venom of the snake Bothrops asper was studied. It was found that, in vitro, most of the venom proteins are similarly ...

Assessing the preclinical efficacy of antivenoms: From the lethality neutralization assay to antivenomics 

Gutiérrez, José María; Solano Trejos, María Gabriela; Pla Ferrer, Davinia; Herrera Vega, María; Segura Ruiz, Álvaro; Villalta Arrieta, Mauren; Vargas Arroyo, Mariángela; Sanz, Libia; Lomonte, Bruno; Calvete Chornet, Juan José; León Montero, Guillermo (2013-07)
The assessment of the capacity of antivenoms to neutralize the lethal activity of snake venoms is the gold standard in the preclinical analysis of antivenom efficacy, and is routinely performed by manufacturers and quality ...

Role of the animal model on the pharmacokinetics of equine-derived antivenoms 

Rojas Araya, Alicia; Vargas Arroyo, Mariángela; Ramírez Arguedas, Nils Antonio; Estrada Umaña, Ricardo; Segura Ruiz, Álvaro; Herrera Vega, María; Villalta Arrieta, Mauren; Gómez Argüello, Aarón; Gutiérrez, José María; León Montero, Guillermo (2013-08)
Antivenom pharmacokinetics has been studied in heterologous models in which the animal species used as immunoglobulin source is different from that used as recipient. In these models, after intravenous administration of ...
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