Browsing Microbiología by Author "Zamunér, Stella Regina"
Now showing items 1-9 of 9
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Bothrops asper and Bothrops jararaca snake venoms trigger microbicidal functions of peritoneal leukocytes in vivo
Zamunér, Stella Regina; Gutiérrez, José María; Muscará, Marcelo N.; Teixeira, Simone A.; Teixeira, Catarina de Fátima (2001-10)Venoms from snakes of the genus Bothrops cause pronounced local effects in the victims. These alterations result not only from the direct toxic action of venom components, but also from the prominent inflammatory reaction ... -
Effects of Bothrops asper snake venom on the expression of cyclooxygenases and production of prostaglandins by peritoneal leukocytes in vivo, and by isolated neutrophils and macrophages in vitro
Moreira, Vanessa; Gutiérrez, José María; Amaral, Rafaela Bacci; Zamunér, Stella Regina; Teixeira, Catarina de Fátima; Amaral, Rafaela Bacci (2009-03)In this study, the ability of Bothrops asper snake venom (BaV) to increase the production of prostaglandins PGE2 and PGD2 was assessed in a mouse model in vivo and in inflammatory cells in vitro. In addition, the expressions ... -
Effects of neutrophil depletion in the local pathological alterations and muscle regeneration in mice injected with Bothrops jararaca snake venom
Teixeira, Catarina de Fátima; Chaves Mora, Fernando; Zamunér, Stella Regina; Fernandes, Cristina Maria; Zuliani, Juliana Pavan; Cruz Höfling, Maria Alice; Fernandes, Irene; Gutiérrez, José María (2005-04)In order to study the role of neutrophils in the acute local pathological alterations induced by Bothrops jararaca snake venom, and in the process of skeletal muscle regeneration that follows, an experimental model was ... -
Inflammation induced by Bothrops asper venom: release of proinflammatory cytokines and eicosanoids, and role of adhesion molecules in leukocyte infiltration
Zamunér, Stella Regina; Zuliani, Juliana Pavan; Fernandes, Cristina Maria; Gutiérrez, José María; Teixeira, Catarina de Fátima (2005-12)Bothrops asper venom (BaV) causes systemic and local effects characterized by an acute inflammatory reaction with accumulation of leukocytes and release of endogenous mediators. In this study, the effects of BaV on the ... -
Inflammatory effects of BaP1 a metalloproteinase isolated from Bothrops asper snake venom: leukocyte recruitment and release of cytokines
Fernandes, Cristina Maria; Zamunér, Stella Regina; Zuliani, Juliana Pavan; Rucavado Romero, Alexandra; Gutiérrez, José María; Teixeira, Catarina de Fátima (2006-04)The inflammatory events induced by BaP1, a 22.7 kDa metalloproteinase isolated from Bothrops asper snake venom, were studied. BaP1 i.p. injection in mice induced a marked inflammatory cell infiltrate into peritoneal cavity ... -
Inflammatory events induced by Lys-49 and Asp-49 phospholipases A2 isolated from Bothrops asper snake venom: role of catalytic activity
Zuliani, Juliana Pavan; Fernandes, Cristina Maria; Zamunér, Stella Regina; Gutiérrez, José María; Teixeira, Catarina de Fátima (2005-03)The inflammatory events induced in the peritoneal cavity of mice by two PLA2s isolated from Bothrops asper snake venom were investigated. MT-III, an Asp-49 catalytically active enzyme and MT-II, a catalytically inactive ... -
Neutrophils do not contribute to local tissue damage, but play a key role in skeletal muscle regeneration, in mice injected with Bothrops asper snake venom
Teixeira, Catarina de Fátima; Zamunér, Stella Regina; Zuliani, Juliana Pavan; Fernandes, Cristina Maria; Cruz Höfling, Maria Alice; Fernandes, Irene; Chaves Mora, Fernando; Gutiérrez, José María (2003-10)Local tissue damage induced by crotaline snake venoms includes edema, myonecrosis, hemorrhage, and an inflammatory response associated with a prominent cellular infiltrate. The role of neutrophils in the local tissue damage ... -
Role of cyclooxygenases in oedema-forming activity of bothropic venoms
Olivo, Renata do A.; Teixeira, Catarina de Fátima; Wallace, John L.; Gutiérrez, José María; Zamunér, Stella Regina (2007-04)The venoms of Bothrops asper (BaV) and Bothrops jararaca (BjV), two of the most medically important poisonous snakes of Latin America, cause pronounced oedema in the victims through poorly understood mechanisms. In the ... -
Secretory phospholipases A2 isolated from Bothrops asper and from Crotalus durissus terrificus snake venoms induce distinct mechanisms for biosynthesis of prostaglandins E2 and D2 and expression of cyclooxygenases
Moreira, Vanessa; Gutiérrez, José María; Soares, Andreimar Martins; Zamunér, Stella Regina; Purgatto, Eduardo; Teixeira, Catarina de Fátima (2008-09-01)The effects of myotoxin III (MT-III), a phospholipase A2 (sPLA2) from Bothrops asper snake venom, and crotoxin B (CB), a neurotoxic and myotoxic sPLA2 from the venom of Crotalus durissus terrificus, on cyclooxygenases ...