Browsing Microbiología by Author "Ward, Richard John"
Now showing items 1-5 of 5
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Amino acid sequence of a myotoxic Lys49-phospholipase A2 homologue from the venom of Cerrophidion (Bothrops) godmani
de Sousa, Marcelo Valle; Morhy, Lauro; Arni, Raghuvir K.; Ward, Richard John; Díaz Oreiro, Cecilia; Gutiérrez, José María (1998-05-19)The complete amino acid sequence of myotoxin II (godMT-II), a myotoxic phospholipase A2 (PLA2) homologue from the venom of the Central American crotaline snake Cerrophidion (Bothrops) godmani, was determined by direct ... -
Crystal structure of myotoxin II, a monomeric Lys49-phospholipase A2 homologue isolated from the venom of Cerrophidion (Bothrops) godmani
Arni, Raghuvir K.; Fontes, Marcos Roberto de Mattos; Barberato, C.; Gutiérrez, José María; Díaz Oreiro, Cecilia; Ward, Richard John (1999-06-15)Lys49-Phospholipase A2 (Lys49-PLA2) homologues damage membranes by a Ca2+-independent mechanism which does not involve catalytic activity. With the aim of determining the structural basis for this novel activity, we have ... -
Dissociation of enzymatic and pharmacological properties of piratoxins-I and -III, two myotoxic phospholipases A2 from Bothrops pirajai snake venom
Soares, Andreimar Martins; Andrião Escarso, Silvia H.; Bortoleto, Raquel K.; Rodrigues Simioni, Lea; Arni, Raghuvir K.; Ward, Richard John; Gutiérrez, José María; Giglio, José Roberto (2001-03-15)Piratoxins (PrTX) I and III are phospholipases A2 (PLA2s) or PLA2 homologue myotoxins isolated from Bothrops pirajai snake venom, which also induce myonecrosis, bactericidal activity against Escherichia coli, disruption ... -
Structure of a calcium-independent phospholipase-like myotoxic protein from Bothrops asper venom
Arni, Raghuvir K.; Ward, Richard John; Gutiérrez, José María; Tulinsky, Alexander (1995-05-01)Myotoxin II, a myotoxic calcium-independent phospholipase-like protein isolated from the venom of Bothrops asper, possesses no detectable phospholipase activity. The crystal structure has been determined and refined at 2.8 ... -
Structure of a Lys49-Phospholipase A2 homologue isolated from the venom of Bothrops nummifer (jumping viper)
de Azevedo, Walter Filgueira; Ward, Richard John; Gutiérrez, José María; Arni, Raghuvir K. (1999-02)Lys49-Phospholipase A2 (Lys49-PLA2) homologues damage membranes by a Ca2+-independent mechanism which does not involve catalytic activity. We have solved the structure of myotoxin-I, a Lys49-PLA2 homologue isolated from ...