Now showing items 1-3 of 3

    • In vivo neutralization of the dendrotoxin-mediated neurotoxicity of black mamba venom by oligoclonal human IgG monoclonal antibodies 

      Laustsen, Andreas Hougaard; Karatt Vellatt, Aneesh; Masters, Edward W.; Arias, Ana Silvia; Pus, Urska; Knudsen, Cecilie; Oscoz, Saioa; Slavny, Peter; Griffiths, Daniel T.; Luther, Alice M.; Leah, Rachael A.; Lindholm, Majken; Lomonte, Bruno; Gutiérrez, José María; McCafferty, John (2018)
      The black mamba (Dendroaspis polylepis) is one of the most feared snake species of the African savanna. It has a potent, fast-acting neurotoxic venom comprised of dendrotoxins and α-neurotoxins associated with high ...
    • Novel snakebite therapeutics must be tested in appropriate rescue models to robustly assess their preclinical efficacy 

      Knudsen, Cecilie; Casewell, Nicholas R.; Lomonte, Bruno; Gutiérrez, José María; Vaiyapuri, Sakthivel; Laustsen, Andreas Hougaard (2020)
      In the field of antivenom research, development, and manufacture, it is often advised to follow the World Health Organization’s (WHO) guidelines for the production, control, and regulation of snake antivenom immunoglobulins, ...
    • Pros and cons of different therapeutic antibody formats for recombinant antivenom development 

      Laustsen, Andreas Hougaard; Gutiérrez, José María; Knudsen, Cecilie; Johansen, Kristoffer H.; Bermúdez Méndez, Erick; Cerni, Felipe A.; Jürgensen, Jonas A.; Ledsgaard, Line; Martos Esteban, Andrea; Øhlenschlæger, Mia; Pus, Urska; Andersen, Mikael Rørdam; Lomonte, Bruno; Engmark, Mikael Gerling; Pucca, Manuela Berto (2018-05)
      Antibody technologies are being increasingly applied in the field of toxinology. Fuelled by the many advances in immunology, synthetic biology, and antibody research, different approaches and antibody formats are being ...