Listar Microbiología por autor "Cintra Francischinelli, Mariana"

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    • Bothrops snake myotoxins induce a large efflux of ATP and potassium with spreading of cell damage and pain 

      Cintra Francischinelli, Mariana; Caccin, Paola; Chiavegato, Angela; Pizzo, Paola; Carmignoto, Giorgio; Angulo Ugalde, Yamileth; Lomonte, Bruno; Gutiérrez, José María; Montecucco, Cesare (2010-07-26)
      Myotoxins play a major role in the pathogenesis of the envenomations caused by snake bites in large parts of the world where this is a very relevant public health problem. We show here that two myotoxins that are major ...

    • Calcium imaging of muscle cells treated with snake myotoxins reveals toxin synergism and presence of acceptors 

      Cintra Francischinelli, Mariana; Pizzo, Paola; Rodrigues Simioni, Lea; Ponce Soto, Luis Alberto; Rossetto, O.; Lomonte, Bruno; Gutiérrez, José María; Pozzan, T.; Montecucco, Cesare (2009-04-17)
      Snake myotoxins have a great impact on human health worldwide. Most of them adopt a phospholipase A2 fold and occur in two forms which often co-exist in the same venom: the Asp49 toxins hydrolyse phospholipids, whilst Lys49 ...

    • The C-terminal region of a Lys49 myotoxin mediates Ca2þ influx in C2C12 myotubes 

      Cintra Francischinelli, Mariana; Pizzo, Paola; Angulo Ugalde, Yamileth; Gutiérrez, José María; Montecucco, Cesare; Lomonte, Bruno (2010-02)
      Myotoxins are abundant components of snake venoms, being a significant public health problem worldwide. Among them, Lys49 phospholipase A2 homologue myotoxins cause extensive necrosis in skeletal muscle tissue. Their ...

    • Why myotoxin-containing snake venoms possess powerful nucleotidases? 

      Caccin, Paola; Pellegatti, Patrizia; Fernández Ulate, Julián; Vono, Maria; Cintra Francischinelli, Mariana; Lomonte, Bruno; Gutiérrez, José María; Di Virgilio, Francesco; Montecucco, Cesare (2013-01-25)
      The venom of the snake Bothrops asper causes muscle necrosis, pain and inflammation. This venom contains myotoxins which cause an increase in intracellular Ca2+ concentration and release of K+ and ATP from myotubes. ATP ...