Now showing items 1-4 of 4

    • Bothrops snake myotoxins induce a large efflux of ATP and potassium with spreading of cell damage and pain 

      Cintra Francischinelli, Mariana; Caccin, Paola; Chiavegato, Angela; Pizzo, Paola; Carmignoto, Giorgio; Angulo Ugalde, Yamileth; Lomonte, Bruno; Gutiérrez, José María; Montecucco, Cesare (2010-07-26)
      Myotoxins play a major role in the pathogenesis of the envenomations caused by snake bites in large parts of the world where this is a very relevant public health problem. We show here that two myotoxins that are major ...
    • Envenomations by Bothrops and Crotalus Snakes Induce the Release of Mitochondrial Alarmins 

      Zornetta, Irene; Caccin, Paola; Fernández Ulate, Julián; Lomonte, Bruno; Gutiérrez, José María; Montecucco, Cesare (PLoS Negl Trop Dis 6(2): e1526, 2012-02-21)
      Skeletal muscle necrosis is a common manifestation of viperid snakebite envenomations. Venoms from snakes of the genus Bothrops, such as that of B. asper, induce muscle tissue damage at the site of venom injection, provoking ...
    • Muscle phospholipid hydrolysis by Bothrops asper Asp49 and Lys49 phospholipase A2 myotoxins – distinct mechanisms of action 

      Fernández Ulate, Julián; Caccin, Paola; Koster, Grielof; Lomonte, Bruno; Gutiérrez, José María; Montecucco, Cesare; Postle, Anthony D. (2013-07-12)
      Bothrops snakes are the major cause of ophidian envenomings in Latin America. Their venom contains myotoxins that cause prominent muscle damage, which may lead to permanent disability. These toxins include myotoxins Mt-I ...
    • Why myotoxin-containing snake venoms possess powerful nucleotidases? 

      Caccin, Paola; Pellegatti, Patrizia; Fernández Ulate, Julián; Vono, Maria; Cintra Francischinelli, Mariana; Lomonte, Bruno; Gutiérrez, José María; Di Virgilio, Francesco; Montecucco, Cesare (2013-01-25)
      The venom of the snake Bothrops asper causes muscle necrosis, pain and inflammation. This venom contains myotoxins which cause an increase in intracellular Ca2+ concentration and release of K+ and ATP from myotubes. ATP ...