Browsing Microbiología by Title
Now showing items 638-657 of 1169
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Inhibition of local hemorrhage and dermonecrosis induced by Bothrops asper snake venom: effectiveness of early in situ administration of the peptidomimetic metalloproteinase inhibitor batimastat and the chelating agent CaNa2EDTA
(2000-11)The effectiveness of the chelating agent CaNa2EDTA and the peptidomimetic matrix metalloproteinase inhibitor batimastat (BB-94) to inhibit local tissue damage induced by Bothrops asper snake venom was studied in mice. Both ... -
Inhibition of Myotoxic Activity of Bothrops asper Myotoxin II by the Anti-trypanosomal Drug Suramin
(2005-06-15)Suramin, a synthetic polysulfonated compound, developed initially for the treatment of African trypanosomiasis and onchocerciasis, is currently used for the treatment of several medically relevant disorders. Suramin, ... -
Inhibition of the hemorrhagic activity of Bothrops asper venom by a novel neutralizing mixture
(1997-06)This study screened 25 sera, 19 synthetic products and five antivenoms obtained after immunization for their ability to neutralize the hemorrhagic activity of venom from the snake Bothrops asper. Among the sera screened, ... -
Inhibition of the myotoxic activity of Bothrops aspermyotoxin II in mice by immunization with its synthetic 13-mer peptide 115-129
(1999)The region comprising amino acid residues 115±129 of myotoxin II, a Lys49 phospholipase A2 from the venom of Bothrops asper, was previously shown to constitute a heparin binding site, and to be associated with its toxic ... -
Inhibition of toxic activities of Bothrops asper venom and other crotalid snake venoms by a novel neutralizing mixture
(1997-12)The majority of snake bites in Central America are caused by Bothrops asper, whose venom induce complex local effects such as myonecrosis, edema and especially hemorrhage. These effects are only partially neutralized by ... -
Inhibitory effect of fucoidan on the activities of crotaline snake venom myotoxic phospholipases A2
(2003)Myotoxic phospholipases A2 account for most of the muscle necrosis that results from envenenomation by crotaline snakes. In this study, we investigated the protective effect of fucoidan, a natural sulfated polysaccharide ... -
Inhibitory effects of Piper umbellatum and Piper peltatum extracts towards myotoxic phospholipases A2 from Bothrops snake venoms: isolation of 4-nerolidylcatechol as active principle
(2005)Phospholipases A2 (PLA2) are important constituents of snake venoms, being responsible for several of their toxic actions. Extracts from plants used in folk medicine were screened for inhibition of the enzymatic activity ... -
Innovative immunization strategies for antivenom development
(2018)Snakes, scorpions, and spiders are venomous animals that pose a threat to human health, and severe envenomings from the bites or stings of these animals must be treated with antivenom. Current antivenoms are based on ... -
Insights into the mutation T1117I in the spike and the lineage B.1.1.389 of SARS-CoV-2 circulating in Costa Rica
(2022-06)Emerging mutations and genotypes of the SARS-CoV-2 virus, responsible for the COVID-19 pandemic, have been reported globally. In Costa Rica during the year 2020, a predominant genotype carrying the mutation T1117I in the ... -
Instituto Clodomiro Picado: Ciencia y Tecnología Endógenas en la Solución de un Problema de la Salud Pública en Centroamérica
(1999-05)El accidente ofídico re-presenta un importante problema de salud pública en Centroamérica. En Costa Rica, por ejemplo, ocurren alrededor de 600 mordeduras por serpientes en humanos anualmente (Gutiérrez, 1995), en tanto ... -
Insulin resistance and impaired glucose tolerance in overweight and obese Costa Rican schoolchildren
(2008)Background. Worldwide obesity has become an unprecedented public health challenge. In addition, a notable increase in the risk of insulin resistance and type 2 diabetes mellitus has emerged. In Costa Rica, there are no ... -
Integrated “omics” profiling indicates that miRNAs are modulators of the ontogenetic venom composition shift in the Central American rattlesnake, Crotalus simus simus
(2013)Background Understanding the processes that drive the evolution of snake venom is a topic of great research interest in molecular and evolutionary toxinology. Recent studies suggest that ontogenetic changes in venom ... -
Integrative characterization of the venom of the coral snake Micrurus dumerilii (Elapidae) from Colombia: proteome, toxicity, and cross-neutralization by antivenom
(2016-03)In Colombia, nearly 2.8% of the 4200 snakebite accidents recorded annually are inflicted by coral snakes (genus Micrurus). Micrurus dumerilii has a broad distribution in this country, especially in densely populated ... -
Interacciones celulares en el proceso de invasión de Shigella sp
(Rev Panam Infectol 2009;11(2):56-61, 2009)Shigella, como agente etiológico de la disentería bacilar, es un problema importante de salud pública a nivel mundial. Para el establecimiento de la infección este microorganismo emplea las funciones celulares y de ... -
Interacción de neutrófilos murinos con Brucella abortus
(2019-12)La brucelosis es una enfermedad zoonótica con distribución mundial. La enfermedad se caracteriza por ocasionar fiebre ondulante en humanos y abortos en animales domésticos como vacas, ovejas, cabras, cerdos y perros. ... -
Interferencia en la cuantificación de electrolitos al emplear tubos con gel separador
(2020-12-15)Los tubos con gel separador para suero sanguíneo se utilizan ampliamente para recolectar, transportar y almacenar muestras de sangre con el fin de realizar ensayos de Química Clínica. Se plantea la necesidad de verificar ... -
Intervenciones terapéuticas en población obesa: Efecto sobre la inflamación
(2021)Actualmente la obesidad es considerada una pandemia y una de las enfermedades no transmisibles más importantes a nivel mundial. Durante las últimas dos décadas, investigaciones han revelado una relación estrecha entre el ... -
Intracellular passage triggers a molecular response in that increases its infectiousness
(2021)Brucella abortus is a facultative extracellular-intracellular pathogen that encounters a diversity of environments within the host cell. We report that bacteria extracted from infected cells at late stages (48 h post-infection) ... -
Intramuscular administration of antivenoms in experimental envenomation by Bothrops asper: comparison between Fab and IgG
(2003-02)The efficacy of intramuscular (im) administration of sheep Fab and IgG antivenoms was assessed in a mouse experimental model of envenomation by Bothrops asper, in order to test if the more rapid absorption of Fab improves ...