• ‘Candidatus Rickettsia nicoyana’: A novel Rickettsia species isolated from Ornithodoros knoxjonesi in Costa Rica 

      Moreira Soto, Rolando Daniel; Moreira Soto, Andrés; Corrales Aguilar, Eugenia; Calderón Arguedas, Ólger; Troyo Rodríguez, Adriana (2017-06)
      Rickettsiae are intracellular bacteria commonly associated with hematophagous arthropods. Most of them have been described in hard ticks, but some have been found in soft ticks. Here we report the detection and isolation ...
    • Detection of an undescribed Rickettsia sp. in Ixodes boliviensis from Costa Rica 

      Troyo Rodríguez, Adriana; Moreira Soto, Andrés; Carranza, Marco V.; Calderón Arguedas, Ólger; Hun Opfer, Ruchilia Laya; Taylor Castillo, Mayra Lizeth (2014)
      Ixodes boliviensis is a tick of carnivores that is common on domestic dogs. The only Rickettsia that has been detected previously in this species is 'Candidatus Rickettsia andeanae'. We report the detection of an undescribed ...
    • Exposure of dogs to spotted fever group rickettsiae in urban sites associated with human rickettsioses in Costa Rica 

      Moreira Soto, Andrés; Carranza, Marco V.; Taylor Castillo, Mayra Lizeth; Calderón Arguedas, Ólger; Hun Opfer, Ruchilia Laya; Troyo Rodríguez, Adriana (2016-07)
      The zoonotic transmission cycles of Rickettsia rickettsii and other spotted fever group (SFG) rickettsiae in Latin America have usually been associated with rural or sylvatic environments, although domestic dogs can be ...
    • First report of acariasis by Caparinia tripilis in African hedgehogs, (Atelerix albiventris), in Costa Rica 

      Moreira Soto, Andrés; Troyo Rodríguez, Adriana; Calderón Arguedas, Ólger (2013)
      The African hedgehog is one of the newly imported exotic pets which have been observed with increasing regularity in veterinary clinics in Costa Rica. Despite their popularity, information about their diseases is scarce. ...
    • Heterologous hyperimmune polyclonal antibodies against SARS-COV-2: A broad coverage, affordable, and scalable potential immunotherapy for Covid-19 

      Alape Girón, Alberto; Moreira Soto, Andrés; Arguedas Gómez, Mauricio; Brenes Porras, Hebleen; Buján Boza, Willem Aart; Corrales Aguilar, Eugenia; Díaz Oreiro, Cecilia; Echeverri McCandless, Ann; Flores Díaz, Marietta; Gómez Argüello, Aarón; Hernández Bolaños, Andrés; Herrera Vega, María; León Montero, Guillermo; Macaya Hayes, Román; Molina Mora, José Arturo; Mora Rodríguez, Javier Francisco; Narayanan, Aarthi; Sanabria Castro, Alfredo; Sánchez Brenes, Andrés; Sánchez Céspedes, Laura Vanessa; Segura Ruiz, Álvaro; Segura Agüero, Eduardo; Solano Centeno, Daniela; Soto Garita, Claudio; Stynoski, Jennifer Lynn; Vargas Arroyo, Mariángela; Villalta Arrieta, Mauren; Drexler, Jan Felix; Gutiérrez, José María (2021-09)
      The emergence and dissemination of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the resulting COVID-19 pandemic triggered a global public health crisis. Although several SARS-CoV-2 vaccines have ...
    • High Efficacy of Therapeutic Equine Hyperimmune Antibodies Against SARS-CoV-2 Variants of Concern 

      Moreira Soto, Andrés; Gutiérrez, José María; Alape Girón, Alberto; Drexler, Jan Felix; Arguedas Gómez, Mauricio; Brenes Porras, Hebleen; Buján Boza, Willem Aart; Corrales Aguilar, Eugenia; Díaz Oreiro, Cecilia; Echeverri McCandless, Ann; Flores Díaz, Marietta; Macaya Hayes, Román; Kühne, Arne; Molina Mora, José Arturo; Mora Rodríguez, Javier Francisco; Sanabria Castro, Alfredo; Sánchez Brenes, Andrés; Sánchez Céspedes, Laura Vanessa; Segura Ruiz, Álvaro; Segura Agüero, Eduardo; Solano Centeno, Daniela; Soto Garita, Claudio; Stynoski, Jennifer Lynn; Vargas Arroyo, Mariángela; Villalta Arrieta, Mauren; Reusken, Chantal B. E. M.; Drosten, Christian (2021)
      SARS-CoV-2 variants of concern show reduced neutralization by vaccine-induced and therapeutic monoclonal antibodies; therefore, treatment alternatives are needed. We tested therapeutic equine polyclonal antibodies (pAbs) ...
    • In vitro Characterization of Anti-SARS-CoV-2 Intravenous Immunoglobulins (IVIg) Produced From Plasma of Donors Immunized With the BNT162b2 Vaccine and Its Comparison With a Similar Formulation Produced From Plasma of COVID-19 Convalescent Donors 

      Rojas Jiménez, Gabriel; Solano Centeno, Daniela; Segura Ruiz, Álvaro; Sánchez Brenes, Andrés; Chaves Araya, Stephanie; Herrera Vega, María; Vargas Arroyo, Mariángela; Cerdas Solís, Maykel; Calvo Salas, Gerardo; Alfaro Alvarado, Jonathan A.; Bolaños Céspedes, Kimberly; Moreira Soto, Andrés; Villalta Arrieta, Mauren; Sánchez Sánchez, Adriana; Cordero Vásquez, Daniel; Durán Blanco, Gina; Solano Blanco, María Gabriela; Gómez Argüello, Aarón; Hernández Bolaños, Andrés; Sánchez Céspedes, Laura Vanessa; Vargas Soto, Marco; Drexler, Jan Felix; Alape Girón, Alberto; Díaz Oreiro, Cecilia; León Montero, Guillermo (2022)
      Despite vaccines are the main strategy to control the ongoing global COVID-19 pandemic, their effectiveness could not be enough for individuals with immunosuppression. In these cases, as well as in patients with ...
    • Neotropical Bats from Costa Rica harbour Diverse Coronaviruses 

      Moreira Soto, Andrés; Taylor Castillo, Mayra Lizeth; Vargas Vargas, Nancy; Rodríguez Herrera, Bernal; Jiménez Centeno, Carlos; Corrales Aguilar, Eugenia (2015-02-04)
      Bats are hosts of diverse coronaviruses (CoVs) known to potentially cross the host–species barrier. For analysing coronavirus diversity in a bat species-rich country, a total of 421 anal swabs/faecal samples from Costa ...
    • Neotropical bats that co-habit with humans function as dead-end hosts for dengue virus 

      Vicente Santos, Amanda; Moreira Soto, Andrés; Soto Garita, Claudio; Chaverri Sánchez, Luis Guillermo; Chaves Ramírez, Andrea; Drexler, Jan Felix; Morales Acuña, Juan Alberto; Alfaro Alarcón, Alejandro; Rodríguez Herrera, Bernal; Corrales Aguilar, Eugenia (2017-05-18)
      Several studies have shown Dengue Virus (DENV) nucleic acids and/or antibodies present in Neotropical wildlife including bats, suggesting that some bat species may be susceptible to DENV infection. Here we aim to elucidate ...
    • Neotropical primary bat cell lines show restricted dengue virus replication 

      Moreira Soto, Andrés; Soto Garita, Claudio; Corrales Aguilar, Eugenia (2017-02)
      Dengue is the most widespread arboviral disease affecting humans. Bats are recognized carriers of emerging viral zoonoses and have been proposed as dengue reservoirs, since RNA/NS1 and/or antiviral antibodies have been ...
    • Pathogenic potential of a Costa Rican strain of ‘Candidatus Rickettsia amblyommii’ in guinea pigs (Cavia porcellus) and protective immunity against Rickettsia rickettsii 

      Rivas Mejías, Juan José; Moreira Soto, Andrés; Alvarado Barboza, Gilberth; Taylor Castillo, Mayra Lizeth; Calderón Arguedas, Ólger; Hun Opfer, Ruchilia Laya; Corrales Aguilar, Eugenia; Morales Acuña, Juan Alberto; Troyo Rodríguez, Adriana (2015-07)
      ‘Candidatus Rickettsia amblyommii’ is a spotted fever group rickettsia that is not considered pathogenic, although there is serologic evidence of possible infection in animals and humans. The aim of this study was to ...
    • SARS-CoV-2 genomic surveillance in Costa Rica: Evidence of a divergent population and an increased detection of a spike T1117I mutation 

      Molina Mora, José Arturo; Cordero Laurent, Estela; Godínez Rojas, Adriana; Calderón Osorno, Melany; Brenes Porras, Hebleen; Soto Garita, Claudio; Pérez Corrales, Cristian; Drexler, Jan Felix; Moreira Soto, Andrés; Corrales Aguilar, Eugenia; Duarte Martínez, Francisco (2021)
      Genome sequencing is a key strategy in the surveillance of SARS-CoV-2, the virus responsible for the COVID-19 pandemic. Latin America is the hardest-hit region of the world, accumulating almost 20% of COVID-19 cases ...
    • Síndrome Respiratorio de Medio Oriente causado por un coronavirus y el Hajj: ¿potencial para una emergencia internacional? 

      Moreira Soto, Andrés; Troyo Rodríguez, Adriana; Corrales Aguilar, Eugenia (2014)
      La epidemiología de enfermedades infecciosas en eventos de concentración masiva requiere de un amplio planeamiento y control por parte de los centros de salud de cada país involucrado. El Síndrome Respiratorio de Medio ...
    • Specific Mutations in the PB2 Protein of Influenza A Virus Compensate for the Lack of Efficient Interferon Antagonism of the NS1 Protein of Bat Influenza A-Like Viruses 

      Aydillo, Teresa; Ayllon, Juan; Pavlisin, Amzie; Martínez Romero, Carles; Tripathi, Shashank; Mena, Ignacio; Moreira Soto, Andrés; Vicente Santos, Amanda; Corrales Aguilar, Eugenia; Schwemmle, Martín; García Sastre, Adolfo (2018-03-14)
      Recently, two new influenza A-like viruses have been discovered in bats, A/little yellow-shouldered bat/Guatemala/060/2010 (HL17NL10) and A/flat-faced bat/Peru/033/2010 (HL18NL11). The hemagglutinin (HA)-like (HL) and ...
    • Virulent Brucella nosferati infecting Desmodus rotundus has emerging potential due to the broad foraging range of its bat host for humans and wild and domestic animals 

      Hernández Mora, Gabriela; Chacón Díaz, Carlos; Moreira Soto, Andrés; Barrantes Granados, Osvaldo; Suárez Esquivel, Marcela; Víquez Ruiz, Eunice; Barquero Calvo, Elías; Ruiz Villalobos, Nazareth; Hidalgo Montealegre, Daniela; González Barrientos, Rocío; Demeter, Elena A.; Estrella Morales, Josimar; Zúñiga Pereira, Ana Mariel; Quesada Gómez, Carlos; Chaves Olarte, Esteban; Lomonte, Bruno; Guzmán Verri, Caterina; Drexler, Jan Felix; Moreno Robles, Edgardo (2023)
      Desmodus rotundus, vampire bats, transmit dangerous infections, and brucellosis is a hazardous zoonotic disease, two adversities that coexist in the subtropical and tropical areas of the American continent. Here, we report ...