Listar Microbiología por autor "505de970-fe2d-422b-8368-eb6df5933a03"
Mostrando ítems 1-4 de 4
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Delayed oral LY333013 rescues mice from highly neurotoxic, lethal doses of Papuan Taipan (Oxyuranus scutellatus) venom
Gutiérrez, José María; Samuel, Stephen P.; Herrera Vega, María; Bryan Quirós, Wendy; Lomonte, Bruno; Bickler, Philip E.; Bulfone, Tommaso C.; Williams, David J. (2018)There is an unmet need for economical snakebite therapies with long shelf lives that are effective even with delays in treatment. The orally bioavailable, heat-stable, secretory phospholipase A2 (sPLA2) inhibitor, LY333013, ... -
Neutralizing properties of Varespladib toward group I and II myotoxic phospholipases A2
Bryan Quirós, Wendy; Fernández Ulate, Julián; Gutiérrez, José María; Lewin, Matthew R.; Lomonte, Bruno (2019)A need exists to develop specific and clinically useful inhibitors of toxic enzymes present in snake venoms, responsible for severe tissue damage and life-threatening effects occurring in thousands of people suffering ... -
Structural basis for phospholipase A2-like toxin inhibition by the synthetic compound Varespladib (LY315920)
Salvador, Guilherme Henrique Marchi; Gomes, Antoniel A. S.; Bryan Quirós, Wendy; Fernández Ulate, Julián; Lewin, Matthew R.; Gutiérrez, José María; Lomonte, Bruno; Fontes, Marcos Roberto de Mattos (2019)The World Health Organization recently listed snakebite envenoming as a Neglected Tropical Disease, proposing strategies to significantly reduce the global burden of this complex pathology by 2030. In this context, ... -
Venom of the Coral Snake Micrurus clarki: Proteomic Profile, Toxicity, Immunological Cross-Neutralization, and Characterization of a Three-Finger Toxin
Lomonte, Bruno; Sasa Marín, Mahmood; Rey Suárez, Paola; Bryan Quirós, Wendy; Gutiérrez, José María (2016)Micrurus clarki is an uncommon coral snake distributed from the Southeastern Pacific of Costa Rica to Western Colombia, for which no information on its venom could be found in the literature. Using a 'venomics' approach, ...