Listar Microbiología por autor "50269408-133c-4c87-8905-c4d179da70c8"
Mostrando ítems 1-20 de 23
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A biocomputational platform for the automated construction of large-scale mathematical models of miRNA-transcription factor networks for studies on gene dosage compensation
Acón, Man Sai; Siles Canales, Francisco; Mora Rodríguez, Rodrigo Antonio (2016-11-09)Cancer complexity and resistance is mediated by cell-to-cell heterogeneity, which is the consequence of the enormous instability of its genetic material. It is unknown how cancer cells are able to withstand the effects ... -
A fluorescence-activatable reporter of flavivirus NS2B–NS3 protease activity enables live imaging of infection in single cells and viral plaques
Arias Arias, Jorge Luis; MacPherson, Derek J.; Hill, Maureen E.; Hardy, Jeanne A.; Mora Rodríguez, Rodrigo Antonio (2020-01-09)The genus Flavivirus in the family Flaviviridae comprises many medically important viruses, such as dengue virus (DENV), Zika virus (ZIKV), and yellow fever virus. The quest for thera- peutic targets to combat flavivirus ... -
A Fluorescent Real-Time Plaque Assay Enables Single-Cell Analysis of Virus-Induced Cytopathic Effect by Live-Cell Imaging
Arias Arias, Jorge Luis; Corrales Aguilar, Eugenia; Mora Rodríguez, Rodrigo Antonio (2021-06-22)Conventional plaque assays rely on the use of overlays to restrict viral infection allowing the formation of distinct foci that grow in time as the replication cycle continues leading to countable plaques that are ... -
A hybrid mathematical modeling approach of the metabolic fate of a fluorescent sphingolipid analogue to predict cancer chemosensitivity
Molina Mora, José Arturo; Kop Montero, Mariana; Quirós Fernández, Isaac; Quirós Barrantes, Steve; Crespo Mariño, Juan Luis; Mora Rodríguez, Rodrigo Antonio (2018-06)Sphingolipid (SL) metabolism is a complex biological system that produces and transforms ceramides and other molecules able to modulate other cellular processes, including survival or death pathways key to cell fate ... -
A Lys49 phospholipase A2 homologue from Bothrops asper snake venom induces proliferation, apoptosis and necrosis in a lymphoblastoid cell line
Mora Rodríguez, Rodrigo Antonio; Valverde Rojas, Berta E.; Díaz Oreiro, Cecilia; Lomonte, Bruno; Gutiérrez, José María (2005-04)Lys49 phospholipase A2 homologues are abundant in viperid snake venoms. These proteins have substitutions at the calcium-binding loop and catalytic center which render them enzymatically inactive; however, they display a ... -
Avances de la bioinformática en Costa Rica: Vista retrospectiva y perspectivas
Campos Sánchez, Rebeca; Flores Cruz, Andrés; Molina Mora, José Arturo; Mora Rodríguez, Rodrigo Antonio; Rodríguez Sánchez, César; Gatica Arias, Andrés Mauricio; Guzmán Verri, Caterina (2021-11-09)Introducción: La disciplina científica de la bioinformática tiene el potencial de generar aplicaciones innovadoras para las sociedades humanas. Costa Rica, pequeña en tamaño y población en comparación con otros países de ... -
Biopiracy of natural products and good bioprospecting practice
Efferth, Thomas; Banerjee, Mita; Paul, Norbert W.; Abdelfatah, Sara; Arend, Joachim; Elhassan, Gihan; Hamdoun, Sami; Hamm, Rebecca; Hong, Chunlan; Kadioglu, Onat; Naß, Janine; Ochwangi, Dominic; Ooko, Edna; Ozenver, Nadire; Saeed, Mohamed E. M.; Schneider, Mathias; Seo, Ean-Jeong; Wu, Ching-Fen; Yan, Ge; Zeino, Maen; Zhao, Qiaoli; Abu Darwish, Mohammad S.; Andersch, Kai; Alexie, Gladys; Bessarab, Dawn; Bhakta Guha, Dipita; Bolzani, Vanderlan; Dapat, Else; Donenko, Fedor V.; Efferth, Monika; Greten, Henry J.; Gunatilaka, Leslie; Hussein, Ahmed A.; Karadeniz, Asuman; Khalid, Hassan E.; Kuete, Victor; Lee, Ik-Soo; Liu, Liang; Midiwo, Jacob; Mora Rodríguez, Rodrigo Antonio; Nakagawa, Hiroshi; Ngassapa, Olipa; Noysang, Chanai; Omosa, Leonida K.; Roland, Fred Hwiemtun; Shahat, Abdelaaty A.; Saab, Antoine; Saeed, Elfatih M.; Shan, Letian; Titinchi, Salam J. J. (2016-02-15)Background: Biopiracy mainly focuses on the use of biological resources and/or knowledge of indigenous tribes or communities without allowing them to share the revenues generated out of economic exploitation or other ... -
Calcium plays a key role in the effects induced by a snake venom Lys49 phospholipase A2 homologue on a lymphoblastoid cell line
Mora Rodríguez, Rodrigo Antonio; Maldonado, Alexis; Valverde Rojas, Berta E.; Gutiérrez, José María (2006-01)A catalytically-inactive Lys49 phospholipase A2 homologue from the venom of the snake Bothrops asper induces diverse effects (necrosis, apoptosis and proliferation) in a lymphoblastoid cell line, depending on the toxin ... -
Characterization of heterogeneous response to chemotherapy by perturbation-based modeling of fluorescent sphingolipid metabolism in cancer cell subpopulations
Mora Rodríguez, Rodrigo Antonio; Molina Mora, José Arturo (2017)Cancer treatments options are limited by the generation of therapy resistance, which is due by intratumoral heterogeneity in cell response. The study of resistance requires biosensors able to report the response at the ... -
Cytotoxicity induced in myotubes by a Lys49 phospholipase A2 homologue from the venom of the snake Bothrops asper: Evidence of rapid plasma membrane damage and a dual role for extracellular calcium
Villalobos Sole, Juan Carlos; Mora Rodríguez, Rodrigo Antonio; Lomonte, Bruno; Gutiérrez, José María; Angulo Ugalde, Yamileth (2007-12)Acute muscle tissue damage, myonecrosis, is a typical consequence of envenomations by snakes of the family Viperidae. Catalytically-inactive Lys49 phospholipase A2 homologues are abundant myotoxic components in viperid ... -
Dengue Virus Infection of Primary Human Smooth Muscle Cells
Arias Arias, Jorge Luis; Vega Aguilar, Francisco; Corrales Aguilar, Eugenia; Hun Opfer, Ruchilia Laya; Loría Masis, Gilbert David; Mora Rodríguez, Rodrigo Antonio (2018-11-05)Dengue virus (DENV) infection of humans is presently the most important arthropod-borne viral global threat, for which no suitable or reliable animal model exists. Reports addressing the effect of DENV on vascular components ... -
Development and validation of fluorescence live-cell imaging approaches to study flavivirus infection kinetics in animal cells
Arias Arias, Jorge Luis (2021-10-07)The genus Flavivirus in the family Flaviviridae comprises many clinically important viruses, such as dengue virus (DENV), Zika virus (ZIKV), and yellow fever virus (YFV). The quest for therapeutic targets to combat ... -
Effects of Bothrops asper snake venom on lymphatic vessels: insights into a hidden aspect of envenomation
Mora Rodríguez, Javier Francisco; Mora Rodríguez, Rodrigo Antonio; Lomonte, Bruno; Gutiérrez, José María (PlosOne 2(10):e318, 2008-10-15)Background: Envenomations by the snake Bothrops asper represent a serious medical problem in Central America and parts of South America. These envenomations concur with drastic local tissue pathology, including a prominent ... -
Fluorescence Imaging Approaches in Flavivirus Research
Arias Arias, Jorge Luis; Mora Rodríguez, Rodrigo Antonio (2021-10-01)The genus Flavivirus within the family Flaviviridae contains many arthropod-borne infectious agents of medical relevance like dengue virus (DENV), Zika virus (ZIKV), and West Nile virus (WNV), among others, that cause ... -
Generation and implementation of reporter BHK-21 cells for live imaging of flavivirus infection
Arias Arias, Jorge Luis; Mora Rodríguez, Rodrigo Antonio (2021-03-05)The genus Flavivirus within the family Flaviviridae includes many viral species of medical importance, such as yellow fever virus (YFV), Zika virus (ZIKV), and dengue virus (DENV), among others. Presently, the identification ... -
Hybrid mathematical modeling decodes the complexity of sphingolipid pathway to predict chemosensitivity
Molina Mora, José Arturo; Quirós Barrantes, Steve; Kop Montero, Mariana; Mora Rodríguez, Rodrigo Antonio; Crespo Mariño, Juan Luis (2017)Sphingolipid (SL) signaling pathway is a complex biological system able to integrate different types of cellular stress signals related to induction of cell death pathways with special interest in cancer. This makes of ... -
Identification of cancer chemosensitivity by ODE and GMM modeling of heterogeneous cellular response to perturbations in fluorescent sphingolipid metabolism
Molina Mora, José Arturo; Mora Rodríguez, Rodrigo Antonio (2016-11-11)Cancer refers to a group of diseases in which cells display uncontrolled growth. Chemotherapy options are usually conditioned by generating resistance which is explained in part by the intrinsic heterogeneity of the ... -
MYC dosage compensation is mediated by miRNA-transcription factor interactions in aneuploid cancer
Acón, Man Sai; Geiß, Carsten; Torres Calvo, Jorge; Bravo Estupiñan, Diana; Oviedo Blanco, Guillermo; Arias Arias, Jorge Luis; Rojas Matey, Luis Andres; Báez Villalobos, Edwin; Vásquez Vargas, Gloriana; Oses Vargas, Yendry; Guevara Coto, José Andrés; Segura Castillo, Andrés; Siles Canales, Francisco; Quirós Barrantes, Steve; Régnier Vigouroux, Anne; Mendes, Pedro; Mora Rodríguez, Rodrigo Antonio (2021-12-17)We hypothesize that dosage compensation of critical genes arises from systems- level properties for cancer cells to withstand the negative effects of aneuploidy. We identified several candidate genes in cancer multiomics ... -
Perturbation-Based Modeling Unveils the Autophagic Modulation of Chemosensitivity and Immunogenicity in Breast Cancer Cells
Quirós Fernández, Isaac; Figueroa Protti, Lucía; Arias Arias, Jorge Luis; Brenes Cordero, Norman; Mora Rodríguez, Javier Francisco; Mora Rodríguez, Rodrigo Antonio (2021-09-18)In the absence of new therapeutic strategies, chemotherapeutic drugs are the most widely used strategy against metastatic breast cancer, in spite of eliciting multiple adverse effects and having low responses with an ... -
Plataforma bioinformática para la identificación de nuevas inferencias del fenómeno de compensación de dosis génica en el panel NCI-60
Torres Calvo, Jorge (2021-12)Las células generan transcritos en respuesta a estímulos internos y externos, siendo algunos codificantes de proteínas y otros no codificantes. Los transcritos que codifican proteínas son regulados por varios elementos, ...