Now showing items 1-19 of 19

    • A novel assay for detecting virus-specific antibodies triggering activation of Fcγ receptors 

      Corrales Aguilar, Eugenia; Trilling, Mirko; Reinhard, Henrike; Mercé Maldonado, Eva; Widera, Marek; Schaal, Heiner; Zimmermann, Albert; Mandelboim, Ofer; Hengel, Hartmut (2013-01-31)
      IgG responses are crucial in antiviral defence and instrumental for the serodiagnosis of infections. Fcγ receptors (FcγRs), which recognize the Fc-part of IgG, differ regarding their IgG binding affinity, IgG subclass ...
    • Arboviral encephalitis in Costa Rican horses: 2009-2016 

      Jiménez Rojas, César; Romero, Mario; Piche Ovares, María Marta; Baldi, Mario; Alfaro Alarcón, Alejandro; Chaves, Andrea; Morales, J.; León Rodríguez, Bernal Alberto; Hutter, Sabine Elisabeth; Corrales Aguilar, Eugenia (2016-12)
      Arbovirus of the genus Alphavirus and Flavivirus can cause febrile illness and sometimes neurological disease in both humans and animals. West Nile Virus (WNV), Eastern Equine Encephalitis Virus (EEEV), Western Equine ...
    • ‘Candidatus Rickettsia nicoyana’: A novel Rickettsia species isolated from Ornithodoros knoxjonesi in Costa Rica 

      Moreira Soto, Rolando Daniel; Moreira Soto, Andrés; Corrales Aguilar, Eugenia; Calderón Arguedas, Ólger; Troyo Rodríguez, Adriana (2017-06)
      Rickettsiae are intracellular bacteria commonly associated with hematophagous arthropods. Most of them have been described in hard ticks, but some have been found in soft ticks. Here we report the detection and isolation ...
    • Chikungunya: un virus que nos acecha 

      Corrales Aguilar, Eugenia; Troyo Rodríguez, Adriana; Calderón Arguedas, Ólger (2015-06-01)
      El virus chikungunya representa una amenaza para Costa Rica. Este arbovirus ha sido introducido al continente americano desde finales de 2013. Debido a sus características epidemiológicas y virológicas, y a la presencia ...
    • CMV-encoded Fcγ receptors: modulators at the interface of innate and adaptive immunity 

      Corrales Aguilar, Eugenia; Hoffmann, Katja; Hengel, Hartmut (2014-10-07)
      The constant region of IgG antibodies mediates antiviral activities upon engaging host Fcγ receptors (FcγRs) expressed by a variety of immune cells, such as antibody-dependent cellullar cytotoxcity (ADCC) executed by natural ...
    • Dengue Virus Infection of Primary Human Smooth Muscle Cells 

      Arias Arias, Jorge Luis; Vega Aguilar, Francisco; Corrales Aguilar, Eugenia; Hun Opfer, Ruchilia Laya; Loría Masis, Gilbert David; Mora Rodríguez, Rodrigo (2018-11-05)
      Dengue virus (DENV) infection of humans is presently the most important arthropod-borne viral global threat, for which no suitable or reliable animal model exists. Reports addressing the effect of DENV on vascular components ...
    • Detección del virus del oeste del Nilo en dos localidades con antecedentes de enfermedad neurológica en equinos: determinación molecular en aves y mosquitos y serología en humanos, aves y equinos 

      Piche Ovares, María Marta (2019-11)
      El virus de Oeste del Nilo (WNV por sus siglas en inglés) es un miembro de la familia Flaviviridae. Su ciclo natural involucra la transmisión entre aves y mosquitos. Las aves son los hospederos y diseminadores del patógeno ...
    • Highly individual patterns of virus‑immune IgG effector responses in humans 

      Corrales Aguilar, Eugenia; Trilling, Mirko; Reinhard, Henrike; Falcone, Valeria; Zimmermann, Albert; Adams, Ortwin; Santibanez, Sabine; Hengel, Hartmut (2016-05-18)
      t IgG responses are fundamental to adaptive immunity and document immunological memory of previous pathogen encounter. While specific antigen recognition is mediated by the variable F(ab′)2 domain of IgG, various effector ...
    • Human Cytomegalovirus Fcγ Binding Proteins gp34 and gp68 Antagonize Fcγ Receptors I, II and III 

      Corrales Aguilar, Eugenia; Trilling, Mirko; Hunold, Katja; Fiedler, Manuela; Le, Vu Thuy Khanh; Reinhard, Henrike; Ehrhardt, Katrin; Mercé Maldonado, Eva; Aliyev, Enver; Zimmermann, Albert; Johnson, David C.; Hengel, Hartmut (2014-05-15)
      Human cytomegalovirus (HCMV) establishes lifelong infection with recurrent episodes of virus production and shedding despite the presence of adaptive immunological memory responses including HCMV immune immunoglobulin G ...
    • Molecular Characterization of Two Major Dengue Outbreaks in Costa Rica 

      Soto Garita, Claudio; Somogyi Pérez, Teresa; Vicente Santos, Amanda; Corrales Aguilar, Eugenia (2016-07)
      Dengue virus (DENV) (Flavivirus, Flaviviridae) is a reemerging arthropod-borne virus with a worldwide circulation, transmitted mainly by Aedes aegypti and Aedes albopictus mosquitoes. Since the first detection of its ...
    • Neotropical Bats from Costa Rica harbour Diverse Coronaviruses 

      Moreira Soto, Andrés; Taylor Castillo, Mayra Lizeth; Vargas Vargas, Nancy; Rodríguez Herrera, Bernal; Jiménez Centeno, Carlos; Corrales Aguilar, Eugenia (2015-02-04)
      Bats are hosts of diverse coronaviruses (CoVs) known to potentially cross the host–species barrier. For analysing coronavirus diversity in a bat species-rich country, a total of 421 anal swabs/faecal samples from Costa ...
    • Neotropical bats that co-habit with humans function as dead-end hosts for dengue virus 

      Vicente Santos, Amanda; Moreira Soto, Andrés; Soto Garita, Claudio; Chaverri Sánchez, Luis Guillermo; Chaves Ramírez, Andrea; Drexler, Jan Felix; Morales Acuña, Juan Alberto; Alfaro Alarcón, Alejandro; Rodríguez Herrera, Bernal; Corrales Aguilar, Eugenia (2017-05-18)
      Several studies have shown Dengue Virus (DENV) nucleic acids and/or antibodies present in Neotropical wildlife including bats, suggesting that some bat species may be susceptible to DENV infection. Here we aim to elucidate ...
    • Neotropical primary bat cell lines show restricted dengue virus replication 

      Moreira Soto, Andrés; Soto Garita, Claudio; Corrales Aguilar, Eugenia (2017-02)
      Dengue is the most widespread arboviral disease affecting humans. Bats are recognized carriers of emerging viral zoonoses and have been proposed as dengue reservoirs, since RNA/NS1 and/or antiviral antibodies have been ...
    • Papel potencial de Aedes albopictus Skuse en la transmisión de virus dengue (DENV) en una zona de actividad piñera de Costa Rica 

      Calderón Arguedas, Ólger; Moreira Soto, Rolando Daniel; Vicente Santos, Amanda; Corrales Aguilar, Eugenia; Rojas Araya, Diana; Troyo Rodríguez, Adriana (2019)
      Objetivo. Evaluar, bajo una perspectiva ecológica, la presencia de Aedes albopictus y su infección natural por virus dengue (DENV) en una zona de actividad piñera de Costa Rica. Método: Se colectaron mosquitos adultos en ...
    • Pathogenic potential of a Costa Rican strain of ‘Candidatus Rickettsia amblyommii’ in guinea pigs (Cavia porcellus) and protective immunity against Rickettsia rickettsii 

      Rivas Mejías, Juan José; Moreira Soto, Andrés; Alvarado Barboza, Gilberth; Taylor Castillo, Mayra Lizeth; Calderón Arguedas, Ólger; Hun Opfer, Ruchilia Laya; Corrales Aguilar, Eugenia; Morales Acuña, Juan Alberto; Troyo Rodríguez, Adriana (2015-07)
      ‘Candidatus Rickettsia amblyommii’ is a spotted fever group rickettsia that is not considered pathogenic, although there is serologic evidence of possible infection in animals and humans. The aim of this study was to ...
    • Síndrome Respiratorio de Medio Oriente causado por un coronavirus y el Hajj: ¿potencial para una emergencia internacional? 

      Moreira Soto, Andrés; Troyo Rodríguez, Adriana; Corrales Aguilar, Eugenia (2014)
      La epidemiología de enfermedades infecciosas en eventos de concentración masiva requiere de un amplio planeamiento y control por parte de los centros de salud de cada país involucrado. El Síndrome Respiratorio de Medio ...
    • Specific Mutations in the PB2 Protein of Influenza A Virus Compensate for the Lack of Efficient Interferon Antagonism of the NS1 Protein of Bat Influenza A-Like Viruses 

      Aydillo, Teresa; Ayllon, Juan; Pavlisin, Amzie; Martínez Romero, Carles; Tripathi, Shashank; Mena, Ignacio; Moreira Soto, Andrés; Vicente Santos, Amanda; Corrales Aguilar, Eugenia; Schwemmle, Martín; García Sastre, Adolfo (2018-03-14)
      Recently, two new influenza A-like viruses have been discovered in bats, A/little yellow-shouldered bat/Guatemala/060/2010 (HL17NL10) and A/flat-faced bat/Peru/033/2010 (HL18NL11). The hemagglutinin (HA)-like (HL) and ...
    • Unexpected Functional Divergence of Bat Influenza Virus NS1 Proteins 

      Turkington, Hannah L.; Juozapaitis, Mindaugas; Tsolakos, Nikos; Corrales Aguilar, Eugenia; Schwemmle, Martín; Hale, Benjamín G. (2018-02-12)
      Recently, two influenza A virus (FLUAV) genomes were identified in Central and South American bats. These sequences exhibit notable divergence from classical FLUAV counterparts, and functionally, bat FLUAV glycoproteins ...
    • El virus del Zika 

      Corrales Aguilar, Eugenia; Soto Garita, Claudio (2016-01)
      El virus del Zika es un arbovirus emergente. Se transmite por medio de los mosquitos del género Aedes. Fue descrito por primera vez en mosquitos y monos del bosque Zika en Uganda, en 1947; posteriormente, en seres humanos ...