Listar Microbiología por autor "43be3542-1a6e-49e9-a385-f31fb431bf14"

Mostrando ítems 1-20 de 28

    • A Fluorescent Real-Time Plaque Assay Enables Single-Cell Analysis of Virus-Induced Cytopathic Effect by Live-Cell Imaging 

      Arias Arias, Jorge Luis; Corrales Aguilar, Eugenia; Mora Rodríguez, Rodrigo Antonio (2021-06-22)
      Conventional plaque assays rely on the use of overlays to restrict viral infection allowing the formation of distinct foci that grow in time as the replication cycle continues leading to countable plaques that are ...

    • A novel assay for detecting virus-specific antibodies triggering activation of Fcγ receptors 

      Corrales Aguilar, Eugenia; Trilling, Mirko; Reinhard, Henrike; Mercé Maldonado, Eva; Widera, Marek; Schaal, Heiner; Zimmermann, Albert; Mandelboim, Ofer; Hengel, Hartmut (2013-01-31)
      IgG responses are crucial in antiviral defence and instrumental for the serodiagnosis of infections. Fcγ receptors (FcγRs), which recognize the Fc-part of IgG, differ regarding their IgG binding affinity, IgG subclass ...

    • Arboviral encephalitis in Costa Rican horses: 2009-2016 

      Jiménez Rojas, César; Romero, Mario; Piche Ovares, María Marta; Baldi, Mario; Alfaro Alarcón, Alejandro; Chaves, Andrea; Morales, J.; León Rodríguez, Bernal Alberto; Hutter, Sabine Elisabeth; Corrales Aguilar, Eugenia (2016-12)
      Arbovirus of the genus Alphavirus and Flavivirus can cause febrile illness and sometimes neurological disease in both humans and animals. West Nile Virus (WNV), Eastern Equine Encephalitis Virus (EEEV), Western Equine ...

    • ‘Candidatus Rickettsia nicoyana’: A novel Rickettsia species isolated from Ornithodoros knoxjonesi in Costa Rica 

      Moreira Soto, Rolando Daniel; Moreira Soto, Andrés; Corrales Aguilar, Eugenia; Calderón Arguedas, Ólger; Troyo Rodríguez, Adriana (2017-06)
      Rickettsiae are intracellular bacteria commonly associated with hematophagous arthropods. Most of them have been described in hard ticks, but some have been found in soft ticks. Here we report the detection and isolation ...

    • Chikungunya: un virus que nos acecha 

      Corrales Aguilar, Eugenia; Troyo Rodríguez, Adriana; Calderón Arguedas, Ólger (2015-06-01)
      El virus chikungunya representa una amenaza para Costa Rica. Este arbovirus ha sido introducido al continente americano desde finales de 2013. Debido a sus características epidemiológicas y virológicas, y a la presencia ...

    • CMV-encoded Fcγ receptors: modulators at the interface of innate and adaptive immunity 

      Corrales Aguilar, Eugenia; Hoffmann, Katja; Hengel, Hartmut (2014-10-07)
      The constant region of IgG antibodies mediates antiviral activities upon engaging host Fcγ receptors (FcγRs) expressed by a variety of immune cells, such as antibody-dependent cellullar cytotoxcity (ADCC) executed by natural ...

    • Dengue Virus Infection of Primary Human Smooth Muscle Cells 

      Arias Arias, Jorge Luis; Vega Aguilar, Francisco; Corrales Aguilar, Eugenia; Hun Opfer, Ruchilia Laya; Loría Masis, Gilbert David; Mora Rodríguez, Rodrigo Antonio (2018-11-05)
      Dengue virus (DENV) infection of humans is presently the most important arthropod-borne viral global threat, for which no suitable or reliable animal model exists. Reports addressing the effect of DENV on vascular components ...

    • Detección del virus del oeste del Nilo en dos localidades con antecedentes de enfermedad neurológica en equinos: determinación molecular en aves y mosquitos y serología en humanos, aves y equinos 

      Piche Ovares, María Marta (2019-11)
      El virus de Oeste del Nilo (WNV por sus siglas en inglés) es un miembro de la familia Flaviviridae. Su ciclo natural involucra la transmisión entre aves y mosquitos. Las aves son los hospederos y diseminadores del patógeno ...

    • Development of an instrument-free and low-cost ELISA dot-blot test to detect antibodies against SARS-CoV-2 

      Apú Leitón, Navilla; Madrigal Redondo, German; Herrera Vega, María; Corrales Aguilar, Eugenia; Segura Ulate, Ismael (2023-02)
      Most laboratory tests to detect the presence of anti-SARS-CoV-2 antibodies use ELISA or CLIA; however, equipment for these immunoassays is unavailable in many areas of low- and middle-income countries. Rapid lateral flow ...

    • Hallazgos histopatológicos asociados a la presencia de arbovirus (chikungunya, zika, dengue, virus del nilo occidental) en murciélagos y aves silvestres en ambientes rurales domiciliares y peridomiciliares 

      Barrantes Murillo, Daniel Felipe (2020)
      Los arbovirus son virus transmitidos por vectores artrópodos. En Costa Rica, circulan algunos como el Dengue, Zika, Chikungunya y Nilo occidental. Los arbovirus poseen dos ciclos ecológicos diferentes para lograr mantenerse ...

    • Heterologous hyperimmune polyclonal antibodies against SARS-COV-2: A broad coverage, affordable, and scalable potential immunotherapy for Covid-19 

      Alape Girón, Alberto; Moreira Soto, Andrés; Arguedas Gómez, Mauricio; Brenes Porras, Hebleen; Buján Boza, Willem Aart; Corrales Aguilar, Eugenia; Díaz Oreiro, Cecilia; Echeverri McCandless, Ann; Flores Díaz, Marietta; Gómez Argüello, Aarón; Hernández Bolaños, Andrés; Herrera Vega, María; León Montero, Guillermo; Macaya Hayes, Román; Molina Mora, José Arturo; Mora Rodríguez, Javier Francisco; Narayanan, Aarthi; Sanabria Castro, Alfredo; Sánchez Brenes, Andrés; Sánchez Céspedes, Laura Vanessa; Segura Ruiz, Álvaro; Segura Agüero, Eduardo; Solano Centeno, Daniela; Soto Garita, Claudio; Stynoski, Jennifer Lynn; Vargas Arroyo, Mariángela; Villalta Arrieta, Mauren; Drexler, Jan Felix; Gutiérrez, José María (2021-09)
      The emergence and dissemination of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the resulting COVID-19 pandemic triggered a global public health crisis. Although several SARS-CoV-2 vaccines have ...

    • High Efficacy of Therapeutic Equine Hyperimmune Antibodies Against SARS-CoV-2 Variants of Concern 

      Moreira Soto, Andrés; Gutiérrez, José María; Alape Girón, Alberto; Drexler, Jan Felix; Arguedas Gómez, Mauricio; Brenes Porras, Hebleen; Buján Boza, Willem Aart; Corrales Aguilar, Eugenia; Díaz Oreiro, Cecilia; Echeverri McCandless, Ann; Flores Díaz, Marietta; Macaya Hayes, Román; Kühne, Arne; Molina Mora, José Arturo; Mora Rodríguez, Javier Francisco; Sanabria Castro, Alfredo; Sánchez Brenes, Andrés; Sánchez Céspedes, Laura Vanessa; Segura Ruiz, Álvaro; Segura Agüero, Eduardo; Solano Centeno, Daniela; Soto Garita, Claudio; Stynoski, Jennifer Lynn; Vargas Arroyo, Mariángela; Villalta Arrieta, Mauren; Reusken, Chantal B. E. M.; Drosten, Christian (2021)
      SARS-CoV-2 variants of concern show reduced neutralization by vaccine-induced and therapeutic monoclonal antibodies; therefore, treatment alternatives are needed. We tested therapeutic equine polyclonal antibodies (pAbs) ...

    • Highly individual patterns of virus‑immune IgG effector responses in humans 

      Corrales Aguilar, Eugenia; Trilling, Mirko; Reinhard, Henrike; Falcone, Valeria; Zimmermann, Albert; Adams, Ortwin; Santibanez, Sabine; Hengel, Hartmut (2016-05-18)
      t IgG responses are fundamental to adaptive immunity and document immunological memory of previous pathogen encounter. While specific antigen recognition is mediated by the variable F(ab′)2 domain of IgG, various effector ...

    • Human Cytomegalovirus Fcγ Binding Proteins gp34 and gp68 Antagonize Fcγ Receptors I, II and III 

      Corrales Aguilar, Eugenia; Trilling, Mirko; Hunold, Katja; Fiedler, Manuela; Le, Vu Thuy Khanh; Reinhard, Henrike; Ehrhardt, Katrin; Mercé Maldonado, Eva; Aliyev, Enver; Zimmermann, Albert; Johnson, David C.; Hengel, Hartmut (2014-05-15)
      Human cytomegalovirus (HCMV) establishes lifelong infection with recurrent episodes of virus production and shedding despite the presence of adaptive immunological memory responses including HCMV immune immunoglobulin G ...

    • In Vitro Inhibition of Zika Virus Replication with Amantadine and Rimantadine Hydrochlorides 

      Arias Arias, Jorge Luis; Vega Aguilar, Francisco; Picado Soto, Dihalá; Corrales Aguilar, Eugenia; Loría Masís, Gilbert David (2021-09-15)
      Zika virus (ZIKV) is a mosquito-borne flavivirus in which human infection became relevant during recent outbreaks in Latin America due to its unrecognized association with fetal neurological disorders. Currently, there ...

    • Infecciones virales en el sistema nervioso central: actualización en la inmunología anti-viral en el sistema nervioso central y evasión inmune viral 

      Ulloa Bermúdez, Luis Miguel (2022)
      Las infecciones en el SNC tienen una gran importancia porque generan una alta mortalidad, además de provocar secuelas importantes en la personas que sobreviven. Muchos agentes virales pueden provocar patologías en el SNC, ...

    • Molecular Characterization of Two Major Dengue Outbreaks in Costa Rica 

      Soto Garita, Claudio; Somogyi Pérez, Teresa; Vicente Santos, Amanda; Corrales Aguilar, Eugenia (2016-07)
      Dengue virus (DENV) (Flavivirus, Flaviviridae) is a reemerging arthropod-borne virus with a worldwide circulation, transmitted mainly by Aedes aegypti and Aedes albopictus mosquitoes. Since the first detection of its ...

    • Neotropical Bats from Costa Rica harbour Diverse Coronaviruses 

      Moreira Soto, Andrés; Taylor Castillo, Mayra Lizeth; Vargas Vargas, Nancy; Rodríguez Herrera, Bernal; Jiménez Centeno, Carlos; Corrales Aguilar, Eugenia (2015-02-04)
      Bats are hosts of diverse coronaviruses (CoVs) known to potentially cross the host–species barrier. For analysing coronavirus diversity in a bat species-rich country, a total of 421 anal swabs/faecal samples from Costa ...

    • Neotropical bats that co-habit with humans function as dead-end hosts for dengue virus 

      Vicente Santos, Amanda; Moreira Soto, Andrés; Soto Garita, Claudio; Chaverri Sánchez, Luis Guillermo; Chaves Ramírez, Andrea; Drexler, Jan Felix; Morales Acuña, Juan Alberto; Alfaro Alarcón, Alejandro; Rodríguez Herrera, Bernal; Corrales Aguilar, Eugenia (2017-05-18)
      Several studies have shown Dengue Virus (DENV) nucleic acids and/or antibodies present in Neotropical wildlife including bats, suggesting that some bat species may be susceptible to DENV infection. Here we aim to elucidate ...

    • Neotropical primary bat cell lines show restricted dengue virus replication 

      Moreira Soto, Andrés; Soto Garita, Claudio; Corrales Aguilar, Eugenia (2017-02)
      Dengue is the most widespread arboviral disease affecting humans. Bats are recognized carriers of emerging viral zoonoses and have been proposed as dengue reservoirs, since RNA/NS1 and/or antiviral antibodies have been ...