Listar Microbiología por autor "3aecd392-24f9-4a13-bf44-80f37ad4dbd3"
Mostrando ítems 1-20 de 34
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A first perturbome of Pseudomonas aeruginosa: Identification of core genes related to multiple perturbations by a machine learning approach
Molina Mora, José Arturo; Montero Manso, Pablo; García Batan, Raquel; Campos Sánchez, Rebeca; Vilar Fernández, José; García Santamaría, Fernando (2021)Tolerance to stress conditions is vital for organismal survival, including bacteria under specific environmental conditions, antibiotics, and other perturbations. Some studies have described common modulation and shared genes ... -
A hybrid mathematical modeling approach of the metabolic fate of a fluorescent sphingolipid analogue to predict cancer chemosensitivity
Molina Mora, José Arturo; Kop Montero, Mariana; Quirós Fernández, Isaac; Quirós Barrantes, Steve; Crespo Mariño, Juan Luis; Mora Rodríguez, Rodrigo Antonio (2018-06)Sphingolipid (SL) metabolism is a complex biological system that produces and transforms ceramides and other molecules able to modulate other cellular processes, including survival or death pathways key to cell fate ... -
Alterations in common marmoset gut microbiome associated with duodenal strictures
Sheh, Alexander; Artim, Stephen C.; Burns, Monika A.; Molina Mora, José Arturo; Lee, Mary Anne; Dzink-Fox, JoAnn; Muthupalani, Sureshkumar; Fox, James G. (2022-03-28)Chronic gastrointestinal (GI) diseases are the most common diseases in captive common marmosets (Callithrix jacchus). Despite standardized housing, diet and husbandry, a recently described gastrointestinal syndrome ... -
Analysis of gut microbiome profiles in common marmosets (Callithrix jacchus) in health and intestinal disease
Sheh, Alexander; Artim, Stephen C.; Burns, Monika A.; Molina Mora, José Arturo; Lee, Mary Anne; Dzink-Fox, JoAnn; Muthupalani, Sureshkumar; Fox, James G. (2022-03-15)Chronic gastrointestinal (GI) diseases are the most common diseases in captive common marmosets. To understand the role of the microbiome in GI diseases, we characterized the gut microbiome of 91 healthy marmosets (303 ... -
Avances de la bioinformática en Costa Rica: Vista retrospectiva y perspectivas
Campos Sánchez, Rebeca; Flores Cruz, Andrés; Molina Mora, José Arturo; Mora Rodríguez, Rodrigo Antonio; Rodríguez Sánchez, César; Gatica Arias, Andrés Mauricio; Guzmán Verri, Caterina (2021-11-09)Introducción: La disciplina científica de la bioinformática tiene el potencial de generar aplicaciones innovadoras para las sociedades humanas. Costa Rica, pequeña en tamaño y población en comparación con otros países de ... -
Characterization of heterogeneous response to chemotherapy by perturbation-based modeling of fluorescent sphingolipid metabolism in cancer cell subpopulations
Mora Rodríguez, Rodrigo Antonio; Molina Mora, José Arturo (2017)Cancer treatments options are limited by the generation of therapy resistance, which is due by intratumoral heterogeneity in cell response. The study of resistance requires biosensors able to report the response at the ... -
Clinical profiles at the time of diagnosis of COVID-19 in Costa Rica during the pre-vaccination period using a machine learning approach
Molina Mora, José Arturo; González Gómez, Alejandra; Jiménez Morgan, Sergio; Cordero Laurent, Estela; Brenes Porras, Hebleen; Soto Garita, Claudio; Sequeira Soto, Jorge; Duarte Martínez, Francisco (2021)Background: The clinical manifestations of COVID-19 disease, caused by the SARS-CoV-2 virus, define a large spectrum of symptoms that are mainly dependent on the human host conditions. In Costa Rica, almost 319 000 cases ... -
Clostridium perfringens Phospholipase C, an Archetypal Bacterial Virulence Factor, induces the Formation of Extracellular Traps by Human Neutrophils
Badilla Vargas, Lisa; Pereira Reyes, Reinaldo; Molina Mora, José Arturo; Alape Girón, Alberto; Flores Díaz, Marietta (2023)Neutrophil extracellular traps (NETs) are networks of DNA and various microbicidal proteins, released to the extracellular space to kill invading microorganisms and prevent their dissemination. However, a NETs excess is ... -
Coinfecciones bacterianas asociadas a la infección por el virus SARS-CoV-2 y su efecto en la resistencia antimicrobiana
Montoya Madriz, Stephanie (2023-07)El virus del SARS-CoV-2 con su consecuente cuadro clínico de COVID-19, surgió en China a finales del 2019. En marzo del 2020 se declaró pandemia y se extendió por aproximadamente tres años. En los casos severos de enfermedad ... -
Elucidating Spirocerca lupi spread in the Americas by using phylogenetic and phylogeographic analyses
Alfaro Segura, Paula; Robleto Quesada, Joby; Montenegro Hidalgo, Víctor M.; Molina Mora, José Arturo; Baneth, Gad; Verocai, Guilherme G.; Rodríguez Vivas, Roger I.; Rojas Araya, Alicia (2023)Spirocerca lupi is a parasitic nematode of domestic and wild canids of the world. This nematode induces esophageal spirocercosis and may eventually lead to carcinomas, aortic aneurisms, and death of the animal. Two genotypes ... -
Gene expression analyses of gingival tissue of patients with periodontitis using public transcriptomic data
Molina Mora, José Arturo; Campos Sánchez, Rebeca; Castro Mora, Milena; Silva de la Fuente, Sandra Maria (2022-11)Abstract—Periodontal disease (PD) is a multifactorial and chronic condition of infection and inflammation of the gingival tissue. However, many of the biological and molecular mechanisms regarding the development of this ... -
Gene Expression Dynamics Induced by Ciprofloxacin and Loss of LexA Function in Pseudomonas aeruginosa PAO1 Using Data Mining and Network Analysis
Molina Mora, José Arturo; Campos Sánchez, Rebeca; García Santamaría, Fernando (2018)Pseudomonas aeruginosa is an opportunistic pathogen that causes a variety of infections in humans and frequently develops mechanisms of resistance to antibiotics, which makes its treatment difficult. In this study we ... -
Genomic context of the two integrons of ST-111 Pseudomonas aeruginosa AG1: A VIM-2-carrying old-acquaintance and a novel IMP-18-carrying integron
Molina Mora, José Arturo; Chinchilla Montero, Diana; García Batan, Raquel; García Santamaría, Fernando (2021)Pseudomonas aeruginosa is an opportunist and versatile organism responsible for infections mainly in immunocompromised hosts. This pathogen has high intrinsic resistance to most antimicrobials. P. aeruginosa AG1 (PaeAG1) ... -
Heterologous hyperimmune polyclonal antibodies against SARS-COV-2: A broad coverage, affordable, and scalable potential immunotherapy for Covid-19
Alape Girón, Alberto; Moreira Soto, Andrés; Arguedas Gómez, Mauricio; Brenes Porras, Hebleen; Buján Boza, Willem Aart; Corrales Aguilar, Eugenia; Díaz Oreiro, Cecilia; Echeverri McCandless, Ann; Flores Díaz, Marietta; Gómez Argüello, Aarón; Hernández Bolaños, Andrés; Herrera Vega, María; León Montero, Guillermo; Macaya Hayes, Román; Molina Mora, José Arturo; Mora Rodríguez, Javier Francisco; Narayanan, Aarthi; Sanabria Castro, Alfredo; Sánchez Brenes, Andrés; Sánchez Céspedes, Laura Vanessa; Segura Ruiz, Álvaro; Segura Agüero, Eduardo; Solano Centeno, Daniela; Soto Garita, Claudio; Stynoski, Jennifer Lynn; Vargas Arroyo, Mariángela; Villalta Arrieta, Mauren; Drexler, Jan Felix; Gutiérrez, José María (2021-09)The emergence and dissemination of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the resulting COVID-19 pandemic triggered a global public health crisis. Although several SARS-CoV-2 vaccines have ... -
High Efficacy of Therapeutic Equine Hyperimmune Antibodies Against SARS-CoV-2 Variants of Concern
Moreira Soto, Andrés; Gutiérrez, José María; Alape Girón, Alberto; Drexler, Jan Felix; Arguedas Gómez, Mauricio; Brenes Porras, Hebleen; Buján Boza, Willem Aart; Corrales Aguilar, Eugenia; Díaz Oreiro, Cecilia; Echeverri McCandless, Ann; Flores Díaz, Marietta; Macaya Hayes, Román; Kühne, Arne; Molina Mora, José Arturo; Mora Rodríguez, Javier Francisco; Sanabria Castro, Alfredo; Sánchez Brenes, Andrés; Sánchez Céspedes, Laura Vanessa; Segura Ruiz, Álvaro; Segura Agüero, Eduardo; Solano Centeno, Daniela; Soto Garita, Claudio; Stynoski, Jennifer Lynn; Vargas Arroyo, Mariángela; Villalta Arrieta, Mauren; Reusken, Chantal B. E. M.; Drosten, Christian (2021)SARS-CoV-2 variants of concern show reduced neutralization by vaccine-induced and therapeutic monoclonal antibodies; therefore, treatment alternatives are needed. We tested therapeutic equine polyclonal antibodies (pAbs) ... -
High quality 3C de novo assembly and annotation of a multidrug resistant ST-111 Pseudomonas aeruginosa genome: Benchmark of hybrid and non-hybrid assemblers
Molina Mora, José Arturo; Campos Sánchez, Rebeca; Rodríguez Sánchez, César; Shi, Leming; García Santamaría, Fernando (2020)Genotyping methods and genome sequencing are indispensable to reveal genomic structure of bacterial species displaying high level of genome plasticity. However, reconstruction of genome or assembly is not straightforward ... -
Hybrid mathematical modeling decodes the complexity of sphingolipid pathway to predict chemosensitivity
Molina Mora, José Arturo; Quirós Barrantes, Steve; Kop Montero, Mariana; Mora Rodríguez, Rodrigo Antonio; Crespo Mariño, Juan Luis (2017)Sphingolipid (SL) signaling pathway is a complex biological system able to integrate different types of cellular stress signals related to induction of cell death pathways with special interest in cancer. This makes of ... -
Identification of cancer chemosensitivity by ODE and GMM modeling of heterogeneous cellular response to perturbations in fluorescent sphingolipid metabolism
Molina Mora, José Arturo; Mora Rodríguez, Rodrigo Antonio (2016-11-11)Cancer refers to a group of diseases in which cells display uncontrolled growth. Chemotherapy options are usually conditioned by generating resistance which is explained in part by the intrinsic heterogeneity of the ... -
Insights into the mutation T1117I in the spike and the lineage B.1.1.389 of SARS-CoV-2 circulating in Costa Rica
Molina Mora, José Arturo (2022-06)Emerging mutations and genotypes of the SARS-CoV-2 virus, responsible for the COVID-19 pandemic, have been reported globally. In Costa Rica during the year 2020, a predominant genotype carrying the mutation T1117I in the ... -
Metagenomic pipeline for identifying co-infections among distinct SARS-CoV-2 variants of concern: Study cases from Alpha to Omicron
Molina Mora, José Arturo; Cordero Laurent, Estela; Calderón Osorno, Melany; Chacón Ramírez, Édgar; Duarte Martínez, Francisco (2022)Concomitant infection or co-infection with distinct SARS-CoV-2 genotypes have been reported as part of the epidemiological surveillance of the COVID-19 pandemic. In the context of the spread of more transmissible variants ...