Now showing items 1-3 of 3

    • A novel assay for detecting virus-specific antibodies triggering activation of Fcγ receptors 

      Corrales Aguilar, Eugenia; Trilling, Mirko; Reinhard, Henrike; Mercé Maldonado, Eva; Widera, Marek; Schaal, Heiner; Zimmermann, Albert; Mandelboim, Ofer; Hengel, Hartmut (2013-01-31)
      IgG responses are crucial in antiviral defence and instrumental for the serodiagnosis of infections. Fcγ receptors (FcγRs), which recognize the Fc-part of IgG, differ regarding their IgG binding affinity, IgG subclass ...
    • Highly individual patterns of virus‑immune IgG effector responses in humans 

      Corrales Aguilar, Eugenia; Trilling, Mirko; Reinhard, Henrike; Falcone, Valeria; Zimmermann, Albert; Adams, Ortwin; Santibanez, Sabine; Hengel, Hartmut (2016-05-18)
      t IgG responses are fundamental to adaptive immunity and document immunological memory of previous pathogen encounter. While specific antigen recognition is mediated by the variable F(ab′)2 domain of IgG, various effector ...
    • Human Cytomegalovirus Fcγ Binding Proteins gp34 and gp68 Antagonize Fcγ Receptors I, II and III 

      Corrales Aguilar, Eugenia; Trilling, Mirko; Hunold, Katja; Fiedler, Manuela; Le, Vu Thuy Khanh; Reinhard, Henrike; Ehrhardt, Katrin; Mercé Maldonado, Eva; Aliyev, Enver; Zimmermann, Albert; Johnson, David C.; Hengel, Hartmut (2014-05-15)
      Human cytomegalovirus (HCMV) establishes lifelong infection with recurrent episodes of virus production and shedding despite the presence of adaptive immunological memory responses including HCMV immune immunoglobulin G ...