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Oral Contraceptives and Cervical Cancer Risk in Costa Rica: Detection Bias or Causal Association
dc.creator | Irwin, Kathleen L. | |
dc.creator | Rosero Bixby, Luis | |
dc.creator | Oberle, Mark W. | |
dc.creator | Lee, Nancy C. | |
dc.creator | Whatley, Anne S. | |
dc.creator | Fortney, Judith A. | |
dc.creator | Bonhomme, Michele G. | |
dc.date.accessioned | 2016-02-09T22:29:43Z | |
dc.date.available | 2016-02-09T22:29:43Z | |
dc.date.issued | 1988-01 | |
dc.identifier.citation | http://www.roserobixby.com/RoseroBixby/Publicaciones_files/101.pdf | |
dc.identifier.citation | http://jama.jamanetwork.com/article.aspx?articleid=370061 | |
dc.identifier.issn | 1538-3598 | |
dc.identifier.uri | https://hdl.handle.net/10669/15569 | |
dc.description | Artículo científico -- Universidad de Costa Rica. Instituto de Investigaciones en Salud, 1988 | es_ES |
dc.description.abstract | To examine the relationship between cervical cancer and oral contraceptive (OC) use, we analyzed data from a population-based, case-control study in Costa Rica. Women aged 25 to 58 years in whom cervical cancer was diagnosed and reported to the National Tumor Registry were examined as two separate case groups: invasive cervical cancer and carcinoma in situ (CIS). Controls were women aged 25 to 58 years identified through a national survey. Women who had used OCs had no increased risk of invasive cervical cancer compared with women who had never used OCs (relative risk, 0.8; 95% confidence interval, 0.5 to 1.3). Women who had used OCs had an increased risk of CIS compared with those who had never used OCs (relative risk, 1.6; 95% confidence interval, 1.2 to 2.2). However, further analyses indicated that this increased risk was confined to those who had recently used OCs. Also, the risk of CIS was not elevated in subgroups in which a history of cervical smears was not strongly linked to OC use. The elevated risk of CIS among (DC users may therefore reflect a bias caused by enhanced detection of disease rather than a causal association. | es_ES |
dc.description.sponsorship | Universidad de Costa Rica. Instituto de Investigaciones en Salud. | es_ES |
dc.language.iso | en_US | es_ES |
dc.source | Journal of the American Medical Association 259 (1): 59-64 | es_ES |
dc.subject | Costa Rica | es_ES |
dc.subject | cervical cancer | es_ES |
dc.subject | oral contraceptive | es_ES |
dc.title | Oral Contraceptives and Cervical Cancer Risk in Costa Rica: Detection Bias or Causal Association | es_ES |
dc.type | artículo original | |
dc.identifier.doi | 10.1001/jama.1988.03720010037037. | |
dc.description.procedence | UCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto de Investigaciones en Salud (INISA) | es_ES |