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dc.creatorFerrera Ferrera, Maura
dc.creatorMalespín Bendaña, Wendy Karina
dc.creatorRamírez Mayorga, Vanessa
dc.creatorGonzález Lutz, María Isabel
dc.creatorCarvajal, Adriana
dc.creatorUne, Clas Allan
dc.date.accessioned2015-12-11T15:56:48Z
dc.date.available2015-12-11T15:56:48Z
dc.date.issued2013
dc.identifier.citationhttp://www.arcmedres.com/article/S0188-4409(13)00183-5/abstract
dc.identifier.urihttps://hdl.handle.net/10669/15366
dc.descriptionArtículo científico -- Universidad de Costa Rica. Instituto de Investigaciones en Salud, 2013. Este documento es privado debido a limitaciones de derechos de autor.es_ES
dc.description.abstractBackground and Aims. Costa Rica has among the highest incidence and mortality rates for gastric cancer worldwide. The reasons for this are largely unknown. Polymorphisms of inflammatory response genes including genes encoding heat shock proteins (HSP) have been shown to be associated with the risk of gastric cancer in some populations. This study addresses the possible association between the HSP70-2 þ1267 and HSP70- Hom þ2437 polymorphisms and the risk of developing gastric cancer in a high-risk population in Costa Rica. Methods. DNA from 39 individuals diagnosed with gastric cancer, 79 healthy controls, 55 individuals with chronic gastritis and 52 individuals with duodenal ulcer was genotyped for the polymorphisms HSP70-2 þ1267 and HSP70-Hom þ2437 by RFLP. Logistic regression analysis was used to determine possible associations with the diagnoses and lineal regression analysis to determine associations with blood pepsinogen (PGs) levels as measured by serology. Results. The GA genotype of HSP70-2 was associated with increased risk of gastric cancer (OR 5 3.42; 95% CI 5 1.27e9.21; p 5 0.015) and duodenal ulcer (OR 5 2.57; 95% CI 5 1.03e6.36; p 5 0.042) as compared to the GG genotype. Persons with C carrier genotypes of HSP70-Hom were significantly less susceptible to gastric cancer than those with the TT genotype (OR 5 0.29; 95% CI 5 0.09e0.87; p 5 0.027). The C carrier genotype was associated with lower PGI concentrations but none of the polymorphisms were associated with PGI/PGII. Conclusions. Polymorphisms of HSP70 genes are associated with the development of gastric cancer and duodenal ulcers in a population at high risk for gastric cancer in Costa Rica.es_ES
dc.description.sponsorshipUniversidad de Costa Rica. Instituto de Investigaciones en Saludes_ES
dc.language.isoen_USes_ES
dc.sourceArchives of Medical Research 44(6): 467- 474es_ES
dc.subjectSalud pública
dc.subjectgastric canceres_ES
dc.subjectduodenal ulceres_ES
dc.subjectchronic gastritises_ES
dc.subjectsingle nucleotide polymorphisms.es_ES
dc.subjectheat shock proteinses_ES
dc.titlePolymorphisms in Genes Coding for HSP-70 Are Associated with Gastric Cancer and Duodenal Ulcer in a Population at High Risk of Gastric Cancer in Costa Ricaes_ES
dc.typeartículo original
dc.identifier.doihttp://dx.doi.org/10.1016/j.arcmed.2013.08.008
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto de Investigaciones en Salud (INISA)es_ES


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