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dc.creatorGutiérrez Espeleta, Gustavo A.
dc.creatorHughes, Lori A.
dc.creatorPiegorsch, Walter W.
dc.creatorShelby, Michael D.
dc.creatorGeneroso, Walderico M.
dc.date.accessioned2015-08-18T20:57:36Z
dc.date.available2015-08-18T20:57:36Z
dc.date.issued1992
dc.identifier.citationhttp://ac.els-cdn.com/027205909290045J/1-s2.0-027205909290045J-main.pdf?_tid=f6e8bb70-42ca-11e5-9409-00000aacb362&acdnat=1439587699_4b70c8eac870cc015ee60be4e08569c2es_ES
dc.identifier.issn0272-0590
dc.identifier.urihttp://hdl.handle.net/10669/15242
dc.descriptionArtículo científico -- Universidad de Costa Rica, Instituto de Investigaciones en Salud. 1992es_ES
dc.description.abstractAcrylamide Is used extensively in sewage and wastewater treatment plants, in the paper and pulp industry, in treatment of potable water, and in research laboratories for chromatography, eltetrophoresis. and electron microscopy. Dermal contact is a major route of human exposure. It has been shown that acrylamide is highly effective in breaking chromosomes of germ cells of male mice and rats when administered intraperitoneally or orally. resulting both in the early death of conceptuses and in :be transmission of reciprocal translocations to live-born progeny, It is now reported that acrylamide is absorbed through the skin of male mice. reaches the germ cells. and induces chromosomal damage. The magnitude of genetic damage appears to be proportional to-the dose administered topically.es_ES
dc.description.sponsorshipUniversidad de Costa Rica, Instituto de Investigaciones en Saludes_ES
dc.language.isoen_USes_ES
dc.sourceFundamental and aplied toxicology 18: 189-192es_ES
dc.subjectacrylamidees_ES
dc.subjectbreaking chromosomeses_ES
dc.subjectgerm cell mutagenicity testses_ES
dc.subjectgenetic damagees_ES
dc.subjectHuman geneticses_ES
dc.subjectSalud públicaes_ES
dc.titleAcrylamide: dermal exposure produces genetic damage in male mouse germ cellses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.typeArtículo científicoes_ES
dc.identifier.doi10.1016/0272-0590(92)90045-J
dc.description.procedenceUCR::Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto de Investigaciones en Salud (INISA)es_ES


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