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dc.creatorSierra Ramos, Rafaela
dc.creatorMuñoz Calero, Nubia
dc.creatorPeña, Salvador
dc.creatorBiemond, I.
dc.creatorvan Duijn, W.
dc.creatorLamers, C. B. H. W.
dc.creatorTeuchmann, Sibylle
dc.creatorHernández, S.
dc.creatorCorrea, P.
dc.date.accessioned2015-08-17T19:57:40Z
dc.date.available2015-08-17T19:57:40Z
dc.date.issued1992-09
dc.identifier.citationhttp://cebp.aacrjournals.org/content/1/6/449.longes_ES
dc.identifier.issn1055-9965
dc.identifier.issn1538-7755
dc.identifier.urihttp://hdl.handle.net/10669/15227
dc.descriptionArtículo científico -- Universidad de Costa Rica. Instituto de Investigaciones en Salud, 1992es_ES
dc.description.abstractIn children and adolescents from two areas of Costa Rica with contrasting gastric cancer risks, two factors suspected to be linked to the natural history of the disease were tested: serum antibodies to Helicobacter pylori and serum pepsinogen levels. One hundred fiftyfive subjects from the high-risk area of Turrubares were compared to 127 from the low-risk area of Hojancha. No significant differences were found in the prevalence of IgG or IgA antibodies to Helicobacter pylori between the two regions. The prevalence of IgG was 65.8% in the high-risk area and 72.4 in the lowrisk area, and that of IgA was 43% in both areas. The levels of pepsinogen, especially pepsinogen C, were significantly elevated in subjects with H. pylori antibodies in their serum. The mean levels of pepsinogen C in those negative, positive, and strong positive for H. pylori antibodies were 8.7, 14.3, and 21.1 ng/ml. These findings suggest that H. pyloriassociated gastritis, predominantly of antral localization, is very prevalent in Costa Rican children and adolescents. Such gastritis might be associated with a high prevalence of intestinal metaplasia and a high gastric cancer risk in the inland, but not the coastal rural populations. H. pylori may therefore be an insufficient cause whose role in gastric carcinogenesis is contingent upon the presence of other factors.es_ES
dc.description.sponsorshipUniversidad de Costa Rica, Instituto de Investigaciones en Saudes_ES
dc.language.isoen_USes_ES
dc.sourceCancer Epidemiology, Biomakers & Prevention 1: 449-454es_ES
dc.subjectfactores de riesgoes_ES
dc.subjectCosta Ricaes_ES
dc.subjectHelicobacter pylories_ES
dc.subjectPepsinogen Levelses_ES
dc.subjectCáncer gástricoes_ES
dc.titleAntibodies to Helicobacter pylori and pepsinogen levels in children from Costa Rica: comparison of two areas with different risks for stomach cánceres_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.typeArtículo científicoes_ES
dc.description.procedenceUCR::Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto de Investigaciones en Salud (INISA)es_ES


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