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dc.creatorde Céspedes Montealegre, Carlos
dc.creatorThoene, J. G.
dc.creatorLowler, K.
dc.creatorChritensen, H. N.
dc.date.accessioned2015-08-14T17:45:57Z
dc.date.available2015-08-14T17:45:57Z
dc.date.issued1992
dc.identifier.issn0141-8955
dc.identifier.issn1573-2665
dc.identifier.urihttps://hdl.handle.net/10669/15210
dc.descriptionArtículo científico -- Universidad de Costa Rica. Instituto de Investigaciones en Salud, 1992es_ES
dc.description.abstractThe mechanism of the observed decrease in the plasma concentration of several amino acids in the presence of high levels of Leu has remained unexplained. In the present study a decrease in the plasma concentration of Ile, Val, Phe, Tyr, Met, Ala, Pro and Gly was observed after the intraperitoneal injection of Leu to weanling rats. Decreases in net intracellular concentrations in muscle accompanied the decrease in plasma of all of these amino acids except Pro and Gly. An increase in the distribution ratio muscle/plasma was observed exclusively for Gly after administration of Leu or of a non-insulinogenic transport system L analogue. Diazoxide suppressed the Leu-induced decreases in plasma and muscle intracellular concentrations of Ile and Val as well as of Pro in plasma. An increase in the distribution ratio liver/plasma was observed for Pro and Gly in the absence but not in the presence of diazoxide. All the above changes were statistically significant. Hence insulin probably mediates Leu effects, promoting an increased utilization of Ile and VaI in muscle and of Pro and GLY. A more direct effect of Leu appears to be involved in the apparent increased utilization of Phe, Tyr and Ala in the same tissue. Gly depletion in plasma can be explained by its trapping by inhibitory action of Leu on the exodus of Gly through transport system L.es_ES
dc.description.sponsorshipUniversidad de Costa Rica. Instituto de Investigaciones en Saludes_ES
dc.language.isoen_USes_ES
dc.sourceJournal of Inherited Metabolic Disease 15: 145-154es_ES
dc.subjectleucemiaes_ES
dc.subjectGlyes_ES
dc.subjectDiazoxidees_ES
dc.subjecttratamientoes_ES
dc.subjectsystem Les_ES
dc.subjectlevels of Leues_ES
dc.titleLeucine and tissue distribution of bulky and small neutral amino acids in rats: dissociation between transport and insulin-mediated effectses_ES
dc.typeartículo original
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto de Investigaciones en Salud (INISA)es_ES


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